RALA Recombinant Rabbit Monoclonal Antibody [JE54-12]

About this product

Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells. During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody. During mitosis, also controls mitochondrial fission by recruiting to the mitochondrion RALBP1, which mediates the phosphorylation and activation of DNM1L by the mitotic kinase cyclin B-CDK1.

Specifications

Catalog number

HA721215

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

MGC48949 antibody Ral a antibody Ral A protein antibody RAL antibody RALA antibody RALA_HUMAN antibody Ras family small GTP binding protein RALA antibody RAS like protein A antibody Ras related protein RalA antibody Ras-related protein Ral-A antibody v ral simian leukemia viral oncogene homolog A (ras related) antibody v ral simian leukemia viral oncogene homolog A antibody

Abbreviation

RALA, RAL

Swiss Prot

P11233 Human

Cellular Locus

Cell membrane, Mitochondrion.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within Human RALA aa 107-206 / 206.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

LOVO cell lysate, HCT116 cell lysate, HT-29 cell lysate, SW480 cell lysate, 293 cell lysate, human kidney tissue lysate, human colon tissue, human colon carcinoma tissue, human kidney tissue, HUVEC.

Concentration

1 mg/mL

Dilution

WB: 1:500 ;IHC-P: 1:200-1:1,000 ;FC:1:500-1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 24 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes