SATB2 Recombinant Rabbit Monoclonal Antibody [PD01-42]

About this product

DNA-binding protein SATB2, also known as Special AT-rich sequence-binding protein 2, is a nuclear matrix-associated transcription factor. SATB2 acts as a docking site for chromatin remodeling enzymes and recruits co-activators and co-repressors to control nuclear gene expression. SATB2 also regulates skeletal development, osteoblast differentiation, and modulates immunoglobulin expression. In normal tissues, strong nuclear SATB2 expression is observed in essentially all glandular cells lining the lower gastrointestinal tract, including the appendix, colon, and rectum. SATB2 is also expressed in a subset of neuronal cells from the cerebral cortex and hippocampus. In tumor tissues, SATB2 is detected in cancer cells of colorectal origin and may function as a clinically useful diagnostic marker for colorectal cancer (CRC). In a multi-cohort study with 1882 primary and metastatic CRCs, SATB2 shows high sensitivity (85%) for CRC, which is further enhanced to 93% when stained in conjunction with Cytokeratin 20. A recent study showed SATB2 expression in 89% of medullary carcinomas of the large intestine. SATB2 has been suggested as a valuable prognostic marker: high SATB2 expression was determined as an independent marker of good prognosis and sensitivity to chemotherapy and radiation in CRC while loss of SATB2 expression was correlated with poor prognosis in laryngeal carcinoma patients.

Specifications

Catalog number

HA721223

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

CAS Number

9000-83-3

Product Name Alternative

DNA binding protein SATB2 antibody DNA-binding protein SATB2 antibody FLJ21474 antibody FLJ32076 antibody GLSS antibody KIAA1034 antibody MGC119474 antibody MGC119477 antibody SATB family member 2 antibody SATB homeobox 2 antibody SATB2 antibody SATB2_HUMAN antibody Special AT rich sequence binding protein 2 antibody Special AT-rich sequence-binding protein 2 antibody

Abbreviation

DNA-binding protein SATB2 Special AT-rich sequence-binding protein 2 SATB2 KIAA1034

Swiss Prot

Q9UPW6 Human

Cellular Locus

Nucleus.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within C terminal human SATB2.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

IHC-P

Positive Control

Human colon tissue, human colon carcinoma tissue, human appendix tissue.

Concentration

1 mg/mL

Dilution

IHC-P: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 82.5 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes