hSET1/SET1 Recombinant Rabbit Monoclonal Antibody [PH00-02]

About this product

Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place. Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis. Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation. Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated.

Specifications

Catalog number

HA721226

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Histone-lysine N-methyltransferase SETD1A antibody hSET1A antibody KMT2F antibody Lysine N methyltransferase 2F antibody Lysine N-methyltransferase 2F antibody SET domain containing 1A antibody SET domain containing protein 1A antibody SET domain-containing protein 1A antibody SET1 antibody Set1 Ash2 histone methyltransferase complex subunit SET1 antibody Set1/Ash2 histone methyltransferase complex subunit SET1 antibody SET1A antibody SET1A_HUMAN antibody SETD1A antibody

Abbreviation

Histone-lysine N-methyltransferase SETD1A Lysine N-methyltransferase 2F SET domain-containing protein 1A (hSET1A) Set1/Ash2 histone methyltransferase complex subunit SET1 SETD1A KIAA0339 KMT2F SET1 SET1A

Swiss Prot

O15047 Human, E9PYH6 Mouse, A0A8I6AS32 Rat

Cellular Locus

Chromosome, Nucleus

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within C terminal human SET1A.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, FC

Positive Control

293T cell lysates, 293T, HepG2.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;FC: 1:500-1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 186 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes