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![Human IL-10 Recombinant Rabbit Monoclonal Antibody [PS00-98] - BSA and Azide free (Capture) — image 1 of 1](https://cdn.genprice.uk/products/992/68dd1c8d061270361ea81f57/imageurl/ha721236.webp)
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Product details
Catalog number HA721236
Price for HA721236
Size / count 100 µL
Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is encoded by the IL10 gene. IL-10 signals through a receptor complex consisting of two IL-10 receptor-1 and two IL-10 receptor-2 proteins. Consequently, the functional receptor consists of four IL-10 receptor molecules. IL-10 binding induces STAT3 signalling via the phosphorylation of the cytoplasmic tails of IL-10 receptor 1 + IL-10 receptor 2 by JAK1 and Tyk2 respectively. IL-10 effects in immunoregulation and inflammation. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10 predominantly inhibits lipopolysaccharide (LPS) and bacterial product mediated induction of the pro-inflammatory cytokines TNFα, IL-1β, IL-12, and IFNγ secretion from Toll-Like Receptor (TLR) triggered myeloid lineage cells.
The catalog number for Human IL-10 Recombinant Rabbit Monoclonal Antibody [PS00-98] - BSA and Azide free (Capture) is HA721236.
Human IL-10 Recombinant Rabbit Monoclonal Antibody [PS00-98] - BSA and Azide free (Capture) is available in the following size(s): 100 µL.
Human IL-10 Recombinant Rabbit Monoclonal Antibody [PS00-98] - BSA and Azide free (Capture) is currently made to order / not held in immediate stock. Contact us for lead time.
Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is encoded by the IL10 gene. IL-10 signals through a receptor complex consisting of two IL-10 receptor-1 and two IL-10 receptor-2 proteins. Consequentl
Reconstitution instructions, including the recommended diluent and final concentration, are provided on the datasheet. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles.
A suggested incubation time is provided in the recommended protocol on the datasheet, but may need adjusting depending on your sample type and detection system.
Inspect the package immediately for transportation damage, ice loss, leakage, or breakage. Report any issues right away with photos and your order reference; our specialists will determine whether the product is still usable or needs replacing.
