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![Human IL-10 Recombinant Rabbit Monoclonal Antibody [PS00-81] - BSA and Azide free (Detector) — image 1 of 1](https://cdn.genprice.uk/products/992/68dd1c90061270361ea82aa7/imageurl/ha721237.webp)
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Product details
Catalog number HA721237
Price for HA721237
Size / count 100 µL
Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is encoded by the IL10 gene. IL-10 signals through a receptor complex consisting of two IL-10 receptor-1 and two IL-10 receptor-2 proteins. Consequently, the functional receptor consists of four IL-10 receptor molecules. IL-10 binding induces STAT3 signalling via the phosphorylation of the cytoplasmic tails of IL-10 receptor 1 + IL-10 receptor 2 by JAK1 and Tyk2 respectively. IL-10 effects in immunoregulation and inflammation. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10 predominantly inhibits lipopolysaccharide (LPS) and bacterial product mediated induction of the pro-inflammatory cytokines TNFα, IL-1β, IL-12, and IFNγ secretion from Toll-Like Receptor (TLR) triggered myeloid lineage cells.
The catalog number for Human IL-10 Recombinant Rabbit Monoclonal Antibody [PS00-81] - BSA and Azide free (Detector) is HA721237.
Human IL-10 Recombinant Rabbit Monoclonal Antibody [PS00-81] - BSA and Azide free (Detector) is available in the following size(s): 100 µL.
Human IL-10 Recombinant Rabbit Monoclonal Antibody [PS00-81] - BSA and Azide free (Detector) is currently made to order / not held in immediate stock. Contact us for lead time.
Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is encoded by the IL10 gene. IL-10 signals through a receptor complex consisting of two IL-10 receptor-1 and two IL-10 receptor-2 proteins. Consequentl
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