Human TNF-beta Recombinant Rabbit Monoclonal Antibody [PS01-19] - BSA and Azide free (Detector)

About this product

Tumor necrosis factor-beta (TNF-β) is a protein that in humans is encoded by the LTA gene. Belonging to the hematopoietic cell line, LT-α exhibits anti-proliferative activity and causes the cellular destruction of tumor cell lines. As a cytotoxic protein, LT-α performs a variety of important roles in immune regulation depending on the form that it is secreted as. Unlike other members of the TNF superfamily, LT-α is only found as a soluble homotrimer, when found at the cell surface it is found only as a heterotrimer with LTβ. LT-α has a significant impact on the maintenance of the immune system including the development of secondary lymphoid organs. Absence of LT-α leads to the disruption of gastrointestinal development, prevents Peyer's patch development, and results in a disorganized spleen. As a signaling molecule, LT-α is involved in the regulation of cell survival, proliferation, differentiation, and apoptosis. LT-α plays an important role in innate immune regulation and its presence has been shown to prevent tumor growth and destroy cancerous cell lines. In contrast, unregulated expression of LT-α can result in a constantly active signaling pathway, thus leading to uncontrolled cellular growth and creation of tumors. Hence depending on the context, LT-α may function to prevent growth of cancer cells or facilitate the development of tumors. Furthermore, LT-α effects depend on the type of organ it acts upon, type of cancer cells, cellular environment, gender, and time of effect during an immune response.

Specifications

Catalog number

HA721243

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

LTalpha antibody DAMA-25N12.13-004 antibody DIF antibody LT alpha antibody LT antibody LT-alpha antibody Lta antibody Lymphotoxin alpha (TNF superfamily, member 1) antibody Lymphotoxin alpha antibody Lymphotoxin-alpha antibody MGC117668 antibody OTTHUMP00000037612 antibody OTTHUMP00000037613 antibody TNF B antibody TNF superfamily member 1 antibody TNF, lymphocyte-derived antibody TNF-beta antibody TNFB antibody TNFB_HUMAN antibody TNFbeta antibody TNFSF 1 antibody TNFSF1 antibody TNLG1E antibody Tumor necrosis factor beta antibody tumor necrosis factor ligand 1E antibody Tumor necrosis factor ligand superfamily member 1 antibody tumor necrosis factor superfamily member 1 antibody

Abbreviation

Lymphotoxin-alpha LT-alpha TNF-beta Tumor necrosis factor ligand superfamily member 1 LTA TNFB TNFSF1

Swiss Prot

P01374 Human

Cellular Locus

Membrane, Secreted

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant full length protein human TNF-beta.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

ELISA (Det)

Positive Control

Recombinant TNF-β protein.

Concentration

1 mg/mL

Dilution

ELISA (Det): Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4).

Molecular Weight

Predicted band size: 22 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes