POMC Recombinant Rabbit Monoclonal Antibody [JE32-88]

About this product

Pro-opiomelanocortin (POMC) is a precursor polypeptide with 241 amino acid residues. POMC is synthesized in corticotrophs of the anterior pituitary from the 267-amino-acid-long polypeptide precursor pre-pro-opiomelanocortin (pre-POMC), by the removal of a 26-amino-acid-long signal peptide sequence during translation. POMC is part of the central melanocortin system. This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.

Specifications

Catalog number

HA721250

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

ACTH antibody Adrenocorticotropic hormone antibody Adrenocorticotropin antibody alpha melanocyte stimulating hormone antibody Alpha MSH antibody Alpha-MSH antibody beta endorphin antibody Beta LPH antibody beta melanocyte stimulating hormone antibody Beta MSH antibody Beta-LPH antibody Beta-MSH antibody CLIP antibody COLI_HUMAN antibody Corticotropin like intermediary peptide antibody Corticotropin lipotropin antibody Corticotropin-lipotropin antibody Gamma MSH antibody Gamma-LPH antibody Gamma-MSH antibody Lipotropin beta antibody Lipotropin gamma antibody LPH antibody Melanotropin alpha antibody Melanotropin antibody Melanotropin beta antibody Melanotropin gamma antibody met enkephalin antibody Met-enkephalin antibody MSH antibody NPP antibody POC antibody POMC antibody pro ACTH endorphin antibody Proopiomelanocortin antibody Proopiomelanocortin preproprotein antibody

Abbreviation

POMC

Swiss Prot

P01189 Human, P01193 Mouse, P01194 Rat

Cellular Locus

Secreted.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human POMC aa 21-70 / 267.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P

Positive Control

Rat pituitary tissue lysates, rat pituitary tissue, mouse pituitary tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IHC-P: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 29 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes