KDM3B Recombinant Rabbit Monoclonal Antibody [PSH0-11]

About this product

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. Its gene is located in the 5q region of the genome which is deleted in del (5q) interstitial deletion, a frequent deletion found in myeloid leukemias and myelodysplasias, suggesting that it may be a good candidate for the del (5q) tumor suppressor gene. A multitude of publications have implicated JMJD1A as a driver of tumorigenesis in a variety of different cancers. Less evidence hints at JMJD1B and JMJD1C as potential oncogenic proteins. And there is persuasive data to suggest that JMJD1B is a tumor suppressor, especially in AML, and JMJD1A and JMJD1C may also be tumor suppressive in germ cell tumors. Tissue specificity: Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver.

Specifications

Catalog number

HA721252

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

5qNCA antibody C5orf7 antibody JHDM2B antibody JmjC domain containing histone demethylation protein 2B antibody JmjC domain-containing histone demethylation protein 2B antibody jmjd1b antibody Jumonji domain containing 1B antibody Jumonji domain containing protein 1B antibody Jumonji domain-containing protein 1B antibody KDM3B antibody KDM3B_HUMAN antibody KIAA1082 antibody Lysine (K) specific demethylase 3B antibody Lysine-specific demethylase 3B antibody NET22 antibody Nuclear protein 5qNCA antibody

Abbreviation

Lysine-specific demethylase 3B JmjC domain-containing histone demethylation protein 2B Jumonji domain-containing protein 1B Nuclear protein 5qNCA [histone H3]-dimethyl-L-lysine (9) demethylase 3B KDM3B C5orf7 JHDM2B JMJD1B KIAA1082

Swiss Prot

Q7LBC6 Human, Q6ZPY7 Mouse

Cellular Locus

Nucleus

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant protein within human KDM3B aa 251-500.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell

Positive Control

Hela cell lysate, NIH/3T3 cell lysate, Hela.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IF-Cell: 1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 191 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes