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![MMAE Recombinant Rabbit Monoclonal Antibody [PSH0-03] — image 1 of 1](https://cdn.genprice.uk/products/992/68dd1c8e061270361ea82367/imageurl/ha721256.webp)
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Product details
Catalog number HA721256
Price for HA721256
Size / count 100 µL
Monomethyl auristatin E is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the antimitotic mechanism. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. In International Nonproprietary Names for MMAE-MAB-conjugates, the name vedotin refers to MMAE plus its linking structure to the antibody. It is a potent antimitotic drug derived from peptides occurring in marine shell-less mollusc Dolabella auricularia called dolastatins which show potent activity in preclinical studies, both in vitro and in vivo, against a range of lymphomas, leukemia and solid tumors. These drugs show potency of up to 200 times that of vinblastine, another antimitotic drug used for Hodgkin lymphoma as well as other types of cancer.
The catalog number for MMAE Recombinant Rabbit Monoclonal Antibody [PSH0-03] is HA721256.
MMAE Recombinant Rabbit Monoclonal Antibody [PSH0-03] is available in the following size(s): 100 µL.
MMAE Recombinant Rabbit Monoclonal Antibody [PSH0-03] is currently made to order / not held in immediate stock. Contact us for lead time.
Monomethyl auristatin E is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the antimitotic mec
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