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![SN38 Recombinant Rabbit Monoclonal Antibody [PSH0-05] — image 1 of 1](https://cdn.genprice.uk/products/992/68dd1c8c061270361ea81a46/imageurl/ha721258.webp)
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Product details
Catalog number HA721258
Price for HA721258
Size / count 100 µL
SN-38 is an antineoplastic drug. It is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor) but has 1000 times more activity than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN-38 relative to irinotecan varies from 2- to 2000-fold. SN38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1. The variant of UGT1A1 in ~10% of Caucasians which leads to poor metabolism of SN-38 predicts irinotecan toxicity, as it is then less easily excreted from the body in its SN-38 glucuronide form. SN-38 and its glucuronide are lost into the bile and intestines. It can cause the symptoms of diarrhoea and myelosuppression experienced by ~25% of the patients administered irinotecan.
The catalog number for SN38 Recombinant Rabbit Monoclonal Antibody [PSH0-05] is HA721258.
SN38 Recombinant Rabbit Monoclonal Antibody [PSH0-05] is available in the following size(s): 100 µL.
SN38 Recombinant Rabbit Monoclonal Antibody [PSH0-05] is currently made to order / not held in immediate stock. Contact us for lead time.
SN-38 is an antineoplastic drug. It is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor) but has 1000 times more activity than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN-38 relative to irinotecan varies from 2- to 2000-fold
We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.
Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.
Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.
