Human TNF alpha Recombinant Rabbit Monoclonal Antibody [PS00-40] - BSA and Azide free (Capture)

Catalog number HA721265

Price for HA721265

Size / count 100 µL

About this product

Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Up-regulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.

Specifications

Catalog number: HA721265
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: APC1 antibody APC1 protein antibody Cachectin antibody DIF antibody Differentiation inducing factor antibody Macrophage cytotoxic factor antibody Tnf antibody TNF superfamily member 2 antibody TNF superfamily, member 2 antibody TNF, macrophage derived antibody TNF, monocyte derived antibody TNF-a antibody TNF-alpha antibody TNFA antibody TNFA_HUMAN antibody TNFSF2 antibody Tumor necrosis factor (TNF superfamily member 2) antibody Tumor necrosis factor alpha antibody Tumor necrosis factor antibody Tumor necrosis factor ligand superfamily member 2 antibody Tumor Necrosis Factor, Membrane Form antibody Tumor necrosis factor, soluble form antibody
Abbreviation: Tumor necrosis factor Cachectin TNF-alpha Tumor necrosis factor ligand superfamily member 2 (TNF-a) Tumor necrosis factor, membrane form Alternative names: N-terminal fragment (NTF) Intracellular domain 1 (ICD1) Intracellular domain 2 (ICD2) C-domain 1 C-domain 2 Tumor necrosis factor, soluble form TNF TNFA, TNFSF2
Swiss Prot: P01375 Human
Cellular Locus: Cell membrane, Secreted.
Host: Rabbit
Species Reactivity: Human
Immunogen: Recombinant protein within full length protein.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: ELISA (Cap)
Positive Control: Recombinant TNF-alpha protein.
Concentration: 1mg/mL
Dilution: ELISA (Cap): Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PS01-07] to TNF alpha (Detector) (HA721266).
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4).
Molecular Weight: Predicted band size: 26 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Human TNF alpha Recombinant Rabbit Monoclonal Antibody [PS00-40] - BSA and Azide free (Capture)?

The catalog number for Human TNF alpha Recombinant Rabbit Monoclonal Antibody [PS00-40] - BSA and Azide free (Capture) is HA721265.

What sizes are available for Human TNF alpha Recombinant Rabbit Monoclonal Antibody [PS00-40] - BSA and Azide free (Capture)?

Human TNF alpha Recombinant Rabbit Monoclonal Antibody [PS00-40] - BSA and Azide free (Capture) is available in the following size(s): 100 µL.

Is Human TNF alpha Recombinant Rabbit Monoclonal Antibody [PS00-40] - BSA and Azide free (Capture) in stock?

Human TNF alpha Recombinant Rabbit Monoclonal Antibody [PS00-40] - BSA and Azide free (Capture) is currently made to order / not held in immediate stock. Contact us for lead time.

What is Human TNF alpha Recombinant Rabbit Monoclonal Antibody [PS00-40] - BSA and Azide free (Capture) used for?

Can this product be used for diagnostic or therapeutic purposes?

No. This product, like all items we supply, is intended for research laboratory use only and must not be used for diagnostics, therapeutics, treatment, or consumption by humans or animals.

What is the shelf life of this product?

Shelf life and expiration dates vary by product and are shown on the product listing and label. Products used beyond their expiration date are not eligible for performance-related returns or refunds, so please check the lot number and expiry before use.

What expression system was used for this recombinant protein?

The expression system, such as E. coli, HEK293, or insect cells, is listed on the datasheet under production details, which can affect post-translational modifications relevant to your application.