CTLA-4 Recombinant Rabbit Monoclonal Antibody [PS01-34]

About this product

CTLA-4 or CTLA4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152 (cluster of differentiation 152), is a protein receptor that functions as an immune checkpoint and downregulates immune responses. CTLA-4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. Variants in this gene have been associated with Type 1 diabetes, Graves' disease, Hashimoto's thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, primary biliary cirrhosis and other autoimmune diseases. Polymorphisms of the CTLA-4 gene are associated with autoimmune diseases such as rheumatoid arthritis, autoimmune thyroid disease and multiple sclerosis, though this association is often weak. In systemic lupus erythematosus (SLE), the splice variant sCTLA-4 is found to be aberrantly produced and found in the serum of patients with active SLE. Germline haploinsufficiency of CTLA-4 leads to CTLA-4 deficiency or CHAI disease (CTLA4 haploinsufficiency with autoimmune infiltration), a rare genetic disorder of the immune system. Symptomatic patients with CTLA-4 mutations are characterized by an immune dysregulation syndrome including extensive T cell infiltration in a number of organs, including the gut, lungs, bone marrow, central nervous system. Once a diagnosis is made, the treatment is based on an individual’s clinical condition and may include standard management for autoimmunity and immunoglobulin deficiencies. The comparatively higher binding affinity of CTLA-4 than CD28 has made it a potential therapy for autoimmune diseases.

Specifications

Catalog number

HA721269

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

ALPS5 antibody CD 152 antibody CD antibody CD152 antibody CD152 antigen antibody CD152 isoform antibody Celiac disease 3 antibody CELIAC3 antibody CTLA 4 antibody CTLA-4 antibody CTLA4 antibody CTLA4_HUMAN antibody Cytotoxic T cell associated 4 antibody Cytotoxic T lymphocyte antigen 4 antibody Cytotoxic T lymphocyte associated 4 antibody Cytotoxic T lymphocyte associated 4, soluble isoform, included antibody Cytotoxic T lymphocyte associated antigen 4 antibody Cytotoxic T lymphocyte associated antigen 4 short spliced form antibody Cytotoxic T lymphocyte associated protein 4 antibody Cytotoxic T lymphocyte associated serine esterase 4 antibody Cytotoxic T lymphocyte protein 4 antibody Cytotoxic T-lymphocyte protein 4 antibody Cytotoxic T-lymphocyte-associated antigen 4 antibody GRD4 antibody GSE antibody ICOS antibody IDDM12 antibody insulin-dependent diabetes mellitus 12 antibody Ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4 antibody OTTHUMP00000216623 antibody

Abbreviation

Cytotoxic T-lymphocyte protein 4 Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) CD152 CTLA4 CD152

Swiss Prot

P16410 Human, P09793 Mouse

Cellular Locus

Cell membrane.

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Synthetic peptide within Human CTLA4 aa 150 to the C-terminus.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

IHC-P

Positive Control

Human tonsil tissue, human lymph nodes tissue.

Concentration

1 mg/mL

Dilution

IHC-P: 1:200-1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 25 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes