p53 Mouse Monoclonal Antibody [C8-A11] — image 1 of 3

Product details

p53 Mouse Monoclonal Antibody [C8-A11]

Catalog number M1312-2

Price for M1312-2

Size / count 100 µL

About this product

Cellular tumor antigen p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor, preventing cancer. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation. Activated p53 binds DNA and activates expression of several genes including microRNA miR-34a, WAF1/CIP1 encoding for p21 and hundreds of other down-stream genes. p21 (WAF1) binds to the G1-S/CDK (CDK2) and S/CDK complexes (molecules important for the G1/S transition in the cell cycle) inhibiting their activity. p53 expression can be stimulated by UV light, which also causes DNA damage. In this case, p53 can initiate events leading to tanning.

Specifications

Catalog number: M1312-2
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: Antigen NY-CO-13 antibody BCC7 antibody Cellular tumor antigen p53 antibody FLJ92943 antibody LFS1 antibody Mutant tumor protein 53 antibody p53 antibody p53 tumor suppressor antibody P53_HUMAN antibody Phosphoprotein p53 antibody Tp53 antibody Transformation related protein 53 antibody TRP53 antibody Tumor protein 53 antibody Tumor protein p53 antibody Tumor suppressor p53 antibody
Abbreviation: TP53
Swiss Prot: P04637 Human
Cellular Locus: Cytoplasm, nucleus
Host: Mouse
Species Reactivity: Human
Immunogen: Synthetic peptide within Human p53 aa 344-393.
Isotype: IgG1
Conjugation: Non-conjugated
Type: Mouse monoclonal Antibody
Applications: WB, IF-Cell, IHC-P
Positive Control: 293, A431, human liver carcinoma tissue
Concentration: 2 mg/mL
Dilution: IF-Cell: 1:500- 1:1,000 ;IHC-P: 1:200 ;WB: 1:500
Purity: Protein G affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: ~53kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for p53 Mouse Monoclonal Antibody [C8-A11]?

The catalog number for p53 Mouse Monoclonal Antibody [C8-A11] is M1312-2.

What sizes are available for p53 Mouse Monoclonal Antibody [C8-A11]?

p53 Mouse Monoclonal Antibody [C8-A11] is available in the following size(s): 100 µL.

Is p53 Mouse Monoclonal Antibody [C8-A11] in stock?

p53 Mouse Monoclonal Antibody [C8-A11] is currently made to order / not held in immediate stock. Contact us for lead time.

What is p53 Mouse Monoclonal Antibody [C8-A11] used for?

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.

Do you offer bulk or custom quantities of this product?

Yes. Ordering two or more units, or combining this with other products, usually qualifies for a discount depending on quantity. Contact our sales team with your required volume for a custom quote.

Do you provide a Certificate of Analysis (CoA) for this product?

A Certificate of Analysis is available for most products upon request. Contact our support team with the lot number to obtain the relevant CoA.