Beta Catenin Mouse Monoclonal Antibody [10-C0-B7] — image 1 of 3

Product details

Beta Catenin Mouse Monoclonal Antibody [10-C0-B7]

Catalog number M1405-6

Price for M1405-6

Size / count 100 µL

About this product

Key downstream component of the canonical Wnt signaling pathway In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle. Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling.

Specifications

Catalog number: M1405-6
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: β Catenin Beta catenin antibody Beta-catenin antibody Cadherin associated protein antibody Catenin (cadherin associated protein), beta 1, 88kDa antibody Catenin beta 1 antibody Catenin beta-1 antibody CATNB antibody CHBCAT antibody CTNB1_HUMAN antibody CTNNB antibody CTNNB1 antibody DKFZp686D02253 antibody FLJ25606 antibody FLJ37923 antibody OTTHUMP00000162082 antibody OTTHUMP00000165222 antibody OTTHUMP00000165223 antibody OTTHUMP00000209288 antibody OTTHUMP00000209289 antibody
Abbreviation: CTNNB1
Swiss Prot: P35222 Human, Q02248 Mouse, Q9WU82 Rat
Cellular Locus: Cytoplasm, nucleus
Host: Mouse
Species Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide within C-terminal human Beta-catenin.
Isotype: IgG2b
Conjugation: Non-conjugated
Type: Mouse monoclonal Antibody
Applications: WB, IF-Cell, IHC-P, FC
Positive Control: Hela, 293T, human colon carcinoma tissue.
Concentration: 2 mg/mL
Dilution: WB: 1:2000 ;IF-Cell: 1:200 ;IHC-P: 1:200 ;FC: 1:100
Purity: Protein G affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: 85 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for Beta Catenin Mouse Monoclonal Antibody [10-C0-B7]?

The catalog number for Beta Catenin Mouse Monoclonal Antibody [10-C0-B7] is M1405-6.

What sizes are available for Beta Catenin Mouse Monoclonal Antibody [10-C0-B7]?

Beta Catenin Mouse Monoclonal Antibody [10-C0-B7] is available in the following size(s): 100 µL.

Is Beta Catenin Mouse Monoclonal Antibody [10-C0-B7] in stock?

Beta Catenin Mouse Monoclonal Antibody [10-C0-B7] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Beta Catenin Mouse Monoclonal Antibody [10-C0-B7] used for?

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.