Alpha-2-macroglobulin Mouse Monoclonal Antibody [B1-D7]

About this product

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Specifications

Catalog number

M1510-24

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

A2m antibody A2MG_HUMAN antibody Alpha 2 M antibody Alpha 2M antibody Alpha-2-M antibody Alpha-2-macroglobulin antibody C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 antibody CPAMD5 antibody DKFZp779B086 antibody FWP007 antibody S863 7 antibody

Abbreviation

Alpha-2-M

Swiss Prot

P01023 Human

Cellular Locus

Secreted.

Host

Mouse

Species Reactivity

Human

Immunogen

Recombinant protein within human Alpha-2-macroglobulin aa 950-1200.

Isotype

IgG1

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IHC-P, ELISA

Positive Control

LO2 cell lysates, human endometrium tissue, human testis tissue, human liver tissue.

Concentration

2 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:2,000 ;ELISA: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 163 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No