human IgM Mouse Monoclonal Antibody [B7-3]

About this product

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V- (D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen. IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions.

Specifications

Catalog number

M1510-5

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

AGM1 antibody Constant region of heavy chain of IgM antibody DKFZp686I15196 antibody DKFZp686I15212 antibody FLJ00385 antibody Hepatitis B virus receptor binding protein antibody Ig mu chain C region antibody IGHM antibody IgM heavy chain constant region antibody Immunoglobulin heavy constant mu antibody Immunoglobulin mu chain antibody Imunoglobulin heavy chain antibody Imunoglobulin heavy chain constant region mu antibody Imunoglobulin heavy chain mu constant region antibody MGC104996 antibody MGC52291 antibody MU antibody VH antibody

Abbreviation

IGHM,Ig mu chain C regionCurated,Ig mu chain C region BOT1 Publication,Ig mu chain C region GAL1 Publication,Ig mu chain C region OU.Immunoglobulin heavy constant m

Swiss Prot

P01871 Human

Cellular Locus

Cell membrane, Immunoglobulin, Membrane, Secreted.

Host

Mouse

Species Reactivity

Human

Immunogen

native protein.

Isotype

IgG1

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IHC-P, ELISA

Positive Control

Recombinant proteint lysates, human liver tissue, mouse spleen tissue.

Concentration

2 mg/mL

Dilution

WB: 1:200-1:500 ;IHC-P: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

50 KD

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No