Cytokeratin 8 Mouse Monoclonal Antibody [A1-B11]

About this product

Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. They have been found to be useful markers of tissue differentiation, which is directly applicable to the characterization of malignant tumors. Cytokeratin 8 expression is seen in epithelium and epithelium-derived tumors. The Cytokeratin 8 and 18 pair are normally expressed in simple epithelia, but not in stratified epithelial cells. Research indicates that squamous cell carcinomas derived from stratified epithelia show abnormal expression of Cytokeratin 8 and 18, although it is not known whether these proteins contribute to the malignant phenotype of the cells. Expression of Cytokeratin 8 and 18 in oral squamous cell carcinomas is an independent prognostic marker that indicates a poor prognosis. Cytokeratin 8 expression correlates with malignancy in leukoplakia and carcinomas of the head and neck; it is expressed in all non-small-cell lung cancers. Cytokeratin 8 has been shown to possess extracellular epitopes on tumor cells, which may represent valuable targets for therapy.

Specifications

Catalog number

M1603-2

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

CARD2 antibody CK 8 antibody CK-8 antibody CK8 antibody CYK8 antibody CYKER antibody Cytokeratin endo A antibody Cytokeratin-8 antibody DreK8 antibody EndoA antibody K2C8 antibody K2C8_HUMAN antibody K8 antibody Keratin 8 antibody Keratin type II cytoskeletal 8 antibody Keratin, type II cytoskeletal 8 antibody Keratin-8 antibody KO antibody Krt 2.8 antibody KRT8 antibody MGC118110 antibody MGC174782 antibody MGC53564 antibody MGC85764 antibody sb:cb186 antibody Type-II keratin Kb8 antibody

Abbreviation

CK-8, K8, KRT8

Swiss Prot

P05787 Human, P11679 Mouse, Q10758 Rat

Cellular Locus

Cytoplasm, Nucleus, Nucleus matrix.

Host

Mouse

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within C-terminal human Cytokeratin 8 aa 441-483.

Isotype

IgG1

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

MCF-7, PANC-1, A549, PC12, human breast carcinoma tissue, human colon cancer tissue, mouse small intestine tissue, Hela.

Concentration

2 mg/mL

Dilution

WB: 1:1,000-1:2,000;IF-Cell: 1:100-1:500;IHC-P: 1:50-1:200;FC: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

53 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No