Hsp90 alpha Mouse Monoclonal Antibody [A10-A5-D2]

About this product

The heat shock response was first described for Drosophila salivary gland cells and morphologically consists of a change in their polytene chromosome puffing patterns that involves de novo synthesis of a few proteins. Similar heat shock proteins were later discovered in bacterial chicken and mammalian cells, and have been subsequently studied in other organisms. A series of proteins including HSP 90, HSP 70, HSP 20-30 and ubiquitin are induced by insults such as temperature shock, chemicals and other environmental stress. A major function of HSP 90 and other HSPs is to act as molecular chaperones. HSP 90 forms a complex with glucocorticoid receptor (GR), rendering the non ligand-bound receptor transcriptionally inactive. HSP 90 binds the GR as a heterocomplex composed of either HSP 56 or Cyclophilin D, forming an aporeceptor comiplex. HSP 90 also exists as a dimer with other proteins such as p60/sti1 and p23, forming an apo-receptor complex with estrogen and androgen receptors.

Specifications

Catalog number

M1603-3

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

EL52 antibody epididymis luminal secretory protein 52 antibody Heat shock 86 kDa antibody heat shock 90kD protein 1, alpha antibody Heat shock 90kD protein 1, alpha like 4 antibody heat shock 90kD protein, alpha-like 4 antibody Heat shock 90kDa protein 1 alpha antibody Heat shock protein 90kDa alpha (cytosolic) class A member 1 antibody Heat shock protein HSP 90-alpha antibody HS90A_HUMAN antibody HSP 86 antibody HSP86 antibody Hsp89 antibody HSP89A antibody Hsp90 antibody HSP90A antibody HSP90AA1 antibody HSP90ALPHA antibody HSP90N antibody HSPC1 antibody HSPCA antibody HSPCAL1 antibody HSPCAL4 antibody HSPN antibody LAP 2 antibody LAP2 antibody lipopolysaccharide-associated protein 2 antibody LPS-associated protein 2 antibody Renal carcinoma antigen NY-REN-38 antibody

Abbreviation

HSP 86, HSP86, LAP-2, LPS-associated protein 2, HSP90AA1

Swiss Prot

P07900 Human

Cellular Locus

Nucleus, Cytoplasm, Melanosome, Cell membrane, Mitochondrion.

Host

Mouse

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human Hsp90 alpha aa 1-50 / 732.

Isotype

IgG1

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

Hela, PC12, NIH/3T3, SW480, Ags, human kidney tissue, human gastric carcinoma tissue, mouse testis tissue.

Concentration

2 mg/mL

Dilution

WB: 1:1,000-1:2,000 ;IF-Cell: 1:100-1:500 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:200

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

90kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No