CD137 Mouse Monoclonal Antibody [2G1]

About this product

CD137, also designated ILA and 4-1BB in mouse, belongs to the tumor necrosis factor receptor family and delivers a costimulatory signal to T lymphocytes. CD137 is expressed on activated T cells and binds an inducible ligand that is found on B cells, macrophages, and dendritic cells. Interactions between CD137 and its ligand are involved in antigen presentation and the generation of cytotoxic T cells. Crosslinking of the CD137 ligand induces apoptosis in resting lymphocytes. In contrast, CD137 regulates peripheral monocyte survival by inducing a cytokine release profile, and is mediated by M-CSF and to a lesser extent by granulocyte-macrophage colony-stimulating factor and IL-3. Soluble forms of CD137 are found in sera from patients with rheumatoid arthritis and may provide a negative control mechanism for immune responses.

Specifications

Catalog number

M1701-11

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

4 1BB antibody 4 1BB ligand receptor antibody 4-1BB ligand receptor antibody 4-1BB Ligand Receptor T Cell antibody 4-1BB, mouse, homolog of antibody Antigen 4-1BB Homolog antibody CD 137 antibody CD137 antibody CD137 antigen antibody CDw137 antibody HLDA VI antibody Homolog of mouse 4 1BB antibody ILA antibody induced by lymphocyte activation (ILA) antibody Induced by lymphocyte activation antibody Interleukin activated receptor homolog of mouse Ly63 antibody Ly63, mouse, homolog of antibody MGC2172 antibody OTTHUMP00000044294 antibody Receptor protein 4 1BB antibody T cell antigen 4 1BB homolog antibody T cell antigen ILA antibody T-cell antigen 4-1BB homolog antibody T-cell antigen ILA antibody TNF receptor superfamily member 9 antibody TNFRSF9 antibody TNR9_HUMAN antibody Tumor necrosis factor receptor superfamily member 9 antibody

Abbreviation

TNFRSF9, CD137, ILA

Swiss Prot

Q07011 Human, P20334 Mouse

Cellular Locus

Membrane. Extracellular space.

Host

Mouse

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant full length protein.

Isotype

IgG1

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IHC-P, IF-Cell, FC

Positive Control

A431, A549, LOVO, rat brain tissue, rat hippocampus tissue, human liver cancer tissue, mouse brain tissue, human tonsil tissue, Jurkat.

Concentration

2 mg/mL

Dilution

WB: 1:500 ;IF-Cell: 1:100-1:500 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 28 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No