LRRK1 Mouse Monoclonal Antibody [5B1] — image 1 of 3

Product details

LRRK1 Mouse Monoclonal Antibody [5B1]

Catalog number M1701-14

Price for M1701-14

Size / count 100 µL

About this product

Leucine-rich repeat serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the LRRK1 gene. Formation of LRRK1:EGF-R complexes result in LRRK cellular translocation: LRRK1 traffics together with EGF-R to endosomes upon stimulation of the receptor with EGF. LRRK1 is related to the familial Parkinsonism gene product Park8/LRRK2, and contains a Ras of complex proteins (ROC) GTPase domain and a MAPKKK-like kinase domain. LRRK1 participates in the intercellular trafficking of the epidermal growth factor (EGF) receptor. LRRK1 is activated by the sequential phosphorylation of 2 mitotic kinases, PLK1 and CDK1. Importantly, this PLK1-dependent activation of LRRK1 is required for the regulation of mitotic spindle orientation.LRRK1 regulates spindle orientation in a manner dependent on its kinase activity. Furthermore, the spindle misorientation caused by PLK1 inactivation is rescued by expression of the phospho-mimicking mutant LRRK1 (S1790D). LRRK1 regulates spindle orientation downstream of PLK1.

Specifications

Catalog number: M1701-14
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: KIAA1790 antibody Leucine rich repeat serine/threonine protein kinase 1 antibody Leucine-rich repeat serine/threonine-protein kinase 1 antibody LRRK 1 antibody Lrrk1 antibody LRRK1_HUMAN antibody RIPK6 antibody Roco1 antibody
Abbreviation: LRRK1, KIAA1790
Swiss Prot: Q38SD2 Human, Q3UHC2 Mouse
Cellular Locus: Cytoplasm.
Host: Mouse
Species Reactivity: Human, Mouse
Immunogen: Recombinant protein within mouse LRRK1 aa 1-164 / 2,015.
Isotype: IgG2b
Conjugation: Non-conjugated
Type: Mouse monoclonal Antibody
Applications: WB, IHC-P
Positive Control: A549, mouse brain tissue, mouse kidney tissue, human kidney tissue.
Concentration: 2 mg/mL
Dilution: WB: 1:500 ;IHC-P: 1:50-1:100
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 225kDa, additional band 60kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for LRRK1 Mouse Monoclonal Antibody [5B1]?

The catalog number for LRRK1 Mouse Monoclonal Antibody [5B1] is M1701-14.

What sizes are available for LRRK1 Mouse Monoclonal Antibody [5B1]?

LRRK1 Mouse Monoclonal Antibody [5B1] is available in the following size(s): 100 µL.

Is LRRK1 Mouse Monoclonal Antibody [5B1] in stock?

LRRK1 Mouse Monoclonal Antibody [5B1] is currently made to order / not held in immediate stock. Contact us for lead time.

What is LRRK1 Mouse Monoclonal Antibody [5B1] used for?

Does this cell line or biologic require a Material Transfer Agreement (MTA)?

Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.