PTBP1 Mouse Monoclonal Antibody [5C1]

About this product

Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a set of polypeptides that contribute to mRNA transcription and pre-mRNA processing as well as mature mRNA transport to the cytoplasm and translation. They also bind heterogeneous nuclear RNA (hnRNA), which are the transcripts produced by RNA polymerase II. There are approximately 20 known hnRNP proteins, and their complexes are the major constituents of the spliceosome. The majority of hnRNP proteins components are localized to the nucleus; however some shuttle between the nucleus and the cytoplasm. hnRNP I, also designated polypyrimidine tract-binding protein (PTB), and its homolog hnRNP L bind to the 3' end of introns to modulate alternative splicing mechanisms of pre-mRNAs in normal cells and the translation of several viruses, including hepatitis C virus (HCV). The human hnRNP I gene maps to chromosome 19p13.3 and encodes a protein that is localized in the nucleoplasm. hnRNP L, like hnRNP I, is also localized in the nucleoplasm.

Specifications

Catalog number

M1701-7

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

57 kDa RNA binding protein PPTB 1 antibody 57 kDa RNA-binding protein PPTB-1 antibody Heterogeneous nuclear ribonucleoprotein I antibody Heterogeneous Nuclear Ribonucleoprotein Polypeptide I antibody hnRNP I antibody HNRNP-I antibody HNRNPI antibody HNRPI antibody MGC10830 antibody MGC8461 antibody Polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I) antibody Polypyrimidine Tract Binding Protein 1 antibody Polypyrimidine tract binding protein antibody Polypyrimidine tract-binding protein 1 antibody pPTB antibody PTB 1 antibody PTB 2 antibody PTB 3 antibody PTB 4 antibody PTB antibody PTB T antibody PTB1 antibody PTB2 antibody PTB3 antibody PTB4 antibody PTBP 1 antibody PTBP1 antibody PTBP1_HUMAN antibody PTBT antibody RNA Binding Protein antibody

Abbreviation

PTB, hnRNP I, PTBP1

Swiss Prot

P26599 Human, P17225 Mouse, Q00438 Rat

Cellular Locus

Nucleus.

Host

Mouse

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human PTBP1 aa 1-50 / 531.

Isotype

IgG1

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IHC-P, IF-Cell

Positive Control

HeLa cell lysate, HepG2 cell lysate, Jurkat cell lysate, K-562 cell lysate, 293T cell lysate, SW620 cell lysate, A431 cell lysate, A549 cell lysate, NIH/3T3 cell lysate, C6 cell lysate, human kidney tissue lysate, mouse kidney tissue lysates, HeLa, human kidney tissue, human colon cancer tissue, human breast cancer tissue, human placental tissue, mouse kidney tissue, rat kidney tissue.

Concentration

2 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:400-1:2,000 ;IF-Cell: 1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 60 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No