GPX5 Mouse Monoclonal Antibody [5A1]

About this product

Glutathione peroxidase (GPx) enzymes are generally selenium-containing tetrameric glycoproteins that help prevent lipid peroxidation of cell membranes. GPx enzymes reduce lipid hydroperoxides to alcohols, and reduce free hydrogen peroxide to water. GPx members are among the few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by the nonsense (stop) codon TGA. There are eight GPx homologs (GPx-1-8). GPx-1, Gpx-2 and Gpx-3 exist as homotetramers. Gpx-4 has a high tendancy to form high molecular weight oligomers. GPx-1 plays an important role in the antioxidant defense of the vascular wall and neural cells in response to oxidative stress. GPx-2 is the major isoform in the lungs and its basal or inducible expression is dependent on Nrf2. GPx-3 is under regulation by hypoxic stress and the expression and deficiency of GPx-3 is associated with cardiovascular disease and stroke. GPx-5 is selenium-independent; it is bound to the acrosome of sperm, where it may protect sperm from premature acrosome reaction in the epididymis.

Specifications

Catalog number

M1701-8

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Arep arMEP24 EGLP Epididymal androgen related protein Epididymal secretory glutathione peroxidase epididymis secretory sperm binding protein Li 75p Epididymis specific glutathione peroxidase like protein Epididymis-specific glutathione peroxidase-like protein Glutathione peroxidase 5 Glutathione peroxidase 5 (epididymal androgen related protein) Glutathione peroxidase, epididymal GPx-5 GPX5 GPX5_HUMAN GSHPx-5 HEL-S-75p Major androgen regulated protein OTTHUMP00000017919 OTTHUMP00000214636

Abbreviation

EGLP, GPx-5, GSHPx-5, GPX5

Swiss Prot

O75715 Human, P21765 Mouse

Cellular Locus

Secreted.

Host

Mouse

Species Reactivity

Human, Mouse

Immunogen

Synthetic peptide within Human GPX5 aa 85-134 / 221.

Isotype

IgG1

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IHC-P, IF-Cell

Positive Control

Human sperm tissue lysates, mouse testis tissue lysates, 293T, Hela, human liver tissue, mouse liver tissue, mouse testis tissue.

Concentration

2 mg/mL

Dilution

WB: 1:500-1:5,000;IHC-P: 1:50-1:200;IF-Cell: 1:50-1:200

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 22 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No