PRMT5 Rabbit Polyclonal Antibody

About this product

This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation, and the assembly of small nuclear ribonucleoproteins. A pseudogene of this gene has been defined on chromosome 4. Alternative splicing results in multiple transcript variants encoding different isoforms. PRMT5 is a highly conserved arginine methyltransferase that translocated from the cytoplasm to the nucleus at embryonic day ~E8.5, and during preimplantation development at the ~4-cell stage. Model organisms have been used in the study of PRMT5 function. A conditional knockout mouse line, called Prmt5tm2a (EUCOMM)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Specifications

Catalog number

R1204-3

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

72 kDa ICln binding protein antibody 72 kDa ICln-binding protein antibody ANM5_HUMAN antibody Histone synthetic lethal 7, S. cerevisiae, homolog of antibody Histone-arginine N-methyltransferase PRMT5 antibody HMT1 hnRNP methyltransferase like 5 antibody HOMOLOG OF; SKB1 antibody HRMT1L5 antibody IBP72 antibody Jak-binding protein 1 antibody JBP 1 antibody JBP1 antibody PRMT 5 antibody PRMT5 antibody Protein arginine methyltransferase 5 antibody Protein arginine N methyltransferase 5 antibody Protein arginine N methyltransferase 5 N terminally processed antibody Protein arginine N-methyltransferase 5 antibody S. POMBE antibody S. POMBE HOMOLOG OF; SKB1 antibody SHK1 KINASE BINDING PROTEIN 1 antibody Shk1 kinase binding protein 1 homolog antibody Shk1 kinase-binding protein 1 homolog antibody Shk1 kinase/binding protein 1, S. pombe, homolog of antibody SKB 1 antibody SKB1 antibody SKB1 homolog antibody SKB1: SKB1 homolog (S. pombe) antibody SKB1Hs antibody

Abbreviation

SKB1 homolog,SKB1Hs

Swiss Prot

O14744 Human, Q8CIG8 Mouse

Cellular Locus

Cytoplasm, nucleus

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Synthetic peptide within N-terminal human Prtm5.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell

Positive Control

HepG2, NCCIT.

Concentration

1 mg/mL

Dilution

WB: 1:500;IF-Cell: 1:50

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

73kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No