Autoimmune regulator (AIRE) Rabbit Polyclonal Antibody

Catalog number R1305-5

Price for R1305-5

Size / count 100 µL

About this product

The Autoimmune Regulator (AIRE) is a human transcription factor expressed at higher level in thymus, pancreas, adrenal cortex, and testis. It is expressed at lower level in the spleen, fetal liver and lymph nodes. It contains zinc finger motifs and isoform 1 is localized to both the nucleus and cytoplasm. Three splice variant mRNAs products have been described. In the thymus it causes transcription of a wide selection of organ-specific genes which create proteins that are usually only expressed in peripheral tissues, creating an "immunological self-shadow" in the thymus. Defects in AIRE are a cause of autoimmune poly-endocrinopathy candidiasis ectodermal dystrophy (APECED), also known as autoimmune polyglandular syndrome type I (APS-1).

Specifications

Catalog number: R1305-5
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: AIRE antibody AIRE_HUMAN antibody AIRE1 antibody APECED antibody APECED protein antibody APS1 antibody APSI antibody Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein antibody Autoimmune regulator antibody Autoimmune regulator protein antibody PGA1 antibody
Abbreviation: APECED protein
Swiss Prot: O43918 Human, Q9Z0E3 Mouse
Cellular Locus: Nucleus, Cytoplasm
Host: Rabbit
Species Reactivity: Human, Mouse
Immunogen: This antibody is produced by immunizing rabbits with full length recombinant protein of mouse AIRE.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: WB
Positive Control: Transfected 293 cell lysates
Concentration: 1 mg/mL
Dilution: WB: 1:2,000
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 58 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for Autoimmune regulator (AIRE) Rabbit Polyclonal Antibody?

The catalog number for Autoimmune regulator (AIRE) Rabbit Polyclonal Antibody is R1305-5.

What sizes are available for Autoimmune regulator (AIRE) Rabbit Polyclonal Antibody?

Autoimmune regulator (AIRE) Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is Autoimmune regulator (AIRE) Rabbit Polyclonal Antibody in stock?

Autoimmune regulator (AIRE) Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is Autoimmune regulator (AIRE) Rabbit Polyclonal Antibody used for?

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.

Can I request a Safety Data Sheet (SDS) for this product?

Yes, safety data sheets are available for hazardous or chemically classified products and can be provided on request or downloaded from the product page.

Can this product be used for co-immunoprecipitation (Co-IP)?

Suitability for Co-IP depends on the specific antibody and is noted under validated applications on the datasheet. If it isn’t listed, contact our technical support team for guidance based on your target and sample type.