Geminin Rabbit Polyclonal Antibody — image 1 of 3

Product details

Geminin Rabbit Polyclonal Antibody

Catalog number R1311-8

Price for R1311-8

Size / count 100 µL

About this product

Geminin is a nuclear protein that is present in most eukaryotics and highly conserved across species. Numerous functions have been elucidated for Geminin including roles in metazoan cell cycle, cellular proliferation, cell lineage commitment, and neural differentiation. Geminin is absent during G1 phase and accumulates through S, G2 phase and M phases of the cell cycle. Geminin levels drop at the metaphase / anaphase transition of mitosis when it is degraded by the Anaphase Promoting Complex (APC/C). During S phase, geminin is a positive regulator of DNA replication. In many cancer cell lines, inhibition of geminin by RNAi results in re-replication of portions of the genome, which leads to aneuploidy. In these cell lines, geminin knockdown leads to markedly slowed growth and apoptosis within several days. Recently, geminin has been found to be overexpressed in several malignancies and cancer cell lines.

Specifications

Catalog number: R1311-8
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: DNA replication inhibitor antibody Gem antibody GEMI_HUMAN antibody Geminin antibody Geminin DNA replication inhibitor antibody GMNN antibody OTTHUMP00000039393 antibody RP3 369A17.3 antibody
Abbreviation: Geminin
Swiss Prot: O88513 Mouse
Cellular Locus: Cytoplasm, nucleus
Host: Rabbit
Species Reactivity: Mouse
Immunogen: Recombinant protein with Mouse Geminin aa 70-206 / 206.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: IF-Cell, IHC-P
Positive Control: F9, D3, human testis tissue.
Concentration: 1 mg/mL
Dilution: IHC-P: 1:100-1:200 ;IF-Cell: 1:200
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 23 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for Geminin Rabbit Polyclonal Antibody?

The catalog number for Geminin Rabbit Polyclonal Antibody is R1311-8.

What sizes are available for Geminin Rabbit Polyclonal Antibody?

Geminin Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is Geminin Rabbit Polyclonal Antibody in stock?

Geminin Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is Geminin Rabbit Polyclonal Antibody used for?

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.

Is this antibody conjugated?

Conjugation status, such as unconjugated, HRP, FITC, or biotin, is specified in the product name and confirmed on the datasheet.

What is the sensitivity of this ELISA kit?

Assay sensitivity, including the minimum detectable dose, is listed on the datasheet. Kits that are assembled on order typically ship within 2-4 weeks.