SRC Rabbit Polyclonal Antibody

About this product

Src (pronounced "sarc" as it is short for sarcoma) is a proto-oncogene encoding a tyrosine kinase. It belongs to a family of non-receptor tyrosine kinases called Src family kinases. c-Src is made up of 6 functional regions: Src homology (SH) 4 domain (SH4 domain), unique region, SH3 domain, SH2 domain, catalytic domain and short regulatory tail. When Src is inactive, the phosphorylated tyrosine group at the 527 position interacts with the SH2 domain which helps the SH3 domain interact with the linker domain and consequently keeps the inactive unit tightly bound. The activation of c-Src causes the dephosphorylation of the tyrosine 527 which causes the structure to be destabilized and then result in the opening up of the SH3, SH2 and the kinase domains and autophosphorylation of tyrosine 416. The activation of the c-Src pathway has been observed in about 50% of tumors from colon, liver, lung, breast and the pancreas.

Specifications

Catalog number

R1312-9

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

ASV antibody Avian sarcoma virus antibody c SRC antibody CDNA FLJ14219 fis clone NT2RP3003800 highly similar to Rattus norvegicus tyrosine protein kinase pp60 c src mRNA antibody cSrc antibody EC 2.7.10.2 antibody Neuronal CSRC tyrosine specific protein kinase antibody Neuronal SRC antibody Oncogene SRC antibody OTTHUMP00000174476 antibody OTTHUMP00000174477 antibody p60 Src antibody p60-Src antibody p60Src antibody pp60c src antibody pp60c-src antibody pp60csrc antibody Proto oncogene tyrosine protein kinase Src antibody Proto-oncogene c-Src antibody Proto-oncogene tyrosine-protein kinase Src antibody Protooncogene SRC antibody Protooncogene SRC Rous sarcoma antibody Src antibody SRC Oncogene antibody SRC proto oncogene non receptor tyrosine kinase antibody SRC_HUMAN antibody SRC1 antibody Tyrosine kinase pp60c src antibody Tyrosine protein kinase SRC 1 antibody Tyrosine protein kinase SRC1 antibody v src avian sarcoma (Schmidt Ruppin A2) viral oncogene homolog antibody V src sarcoma (Schmidt Ruppin A 2) viral oncogene homolog (avian) antibody v src sarcoma (Schmidt Ruppin A 2) viral oncogene homolog avian antibody

Abbreviation

p60-Src

Swiss Prot

P12931 Human, P05480 Mouse, Q9WUD9 Rat

Cellular Locus

Cell membrane, nucleus, cytoplasm

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within C-terminalhuman SRC.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell

Positive Control

Jurkat, PC12, Hela

Concentration

1 mg/mL

Dilution

WB: 1:1000-1:2000;IF-Cell: 1:100-1:200

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 60 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No