TCF7L2/TCF4 Rabbit Polyclonal Antibody

About this product

TCF7L2 is a transcription factor influencing the transcription of several genes thereby exerting a large variety of functions within the cell. It is a member of the Wnt signaling pathway. Stimulation of the pathway leads to the association of β-catenin with BCL9, translocation to the nucleus, and association with TCF7L2, which in turn results in the activation of Wnt target genes, specifically repressing proglucagon synthesis in enteroendocrine cells. TCF7L2 is implicated in a large variety of diseases. Several single nucleotide polymorphisms are associated with type 2 diabetes. In European populations it was found to be a major determinant of type 2 risk. A frameshift mutation of TCF7L2 is implicated in colorectal cancer .Variants of the gene are most likely involved in many other cancer types

Specifications

Catalog number

R1401-11

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

CAS Number

9007-83-4

Product Name Alternative

bHLHb19 antibody Class B basic helix-loop-helix protein 19 antibody E2 2 antibody FECD3 antibody Immunoglobulin transcription factor 2 antibody ITF 2 antibody ITF-2 antibody ITF2 antibody ITF2_HUMAN antibody MGC149723 antibody MGC149724 antibody PTHS antibody SEF 2 antibody SEF-2 antibody SEF2 1 antibody SEF2 1A antibody SEF2 1B antibody SEF2 1D antibody SEF2 antibody SL3 3 enhancer factor 2 antibody SL3-3 enhancer factor 2 antibody TCF 4 antibody TCF-4 antibody TCF4 antibody Transcription factor 4 antibody Transcription factor 4, isoform C antibody Transcription factor 4, isoform D antibody Transcription factor 4, isoform E antibody Transcription factor 4, isoform L antibody Transcription factor 4, isoform M antibody Transcription factor 4, isoform R antibody

Abbreviation

T-cell factor 4,TCF-4,hTCF-4

Swiss Prot

Q9NQB0 Human, Q924A0 Mouse, D3Z9D1 Rat

Cellular Locus

Nucleus

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within N-terminalHuman TCF4 aa 1-50 / 619.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, IF-Cell, FC

Positive Control

Hela, HepG2, HCT116, SW480, rat kidney tissue, human tonsil tissue, human colon cancer tissue, human breast cancer tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:2,000;IF-Cell: 1:500-1:2,000;IHC-P: 1:100-1:500;FC: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 68 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No