CUGBP Elav-like family member 2 Rabbit Polyclonal Antibody

About this product

Myotonic dystrophy (DM) is an autosomal dominant neuromuscular disease that is associated with a (CTG)n repeat expansion in the 3'-untranslated region of the myotonin protein kinase gene (DMPK). CUG-BP1 and CUG-BP2 are proteins that bind specifically to (CUG)8 oligonucleotides in vitro. While CUG-BP1 has the major binding activity in normal cells, nuclear CUG-BP2 binding activity increases in DM cells. Both CUG-BP1 and CUG-BP2 are isoforms of a novel heterogeneous nuclear ribonucleoprotein (hnRNP), hNab50. CUG-BP1, an RNA CUG triplet repeat binding protein, regulates splicing and translation of various RNAs. Expansion of RNA CUG repeats in the DMPK in DM is associated with alterations in binding activity of CUG-BP1 as well as alterations in the translation of the C/EBPb transcription factor. CUG-BP1 is an important regulator of initiation from different AUG codons of C/EBPb mRNA. In normal cells, CUG-BP1 up-regulates the p21 protein during differentiation by inducing the translation of p21 via binding to a GC-rich sequence located within the 5' region of p21 mRNA. In DM cells, failure to accumulate CUG-BP1 leads to a reduction of p21 and alterations in other proteins responsible for cell cycle withdrawl.

Specifications

Catalog number

R1403-3

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Bruno-like protein 3 antibody BRUNOL3 antibody Cardiac elav type RNA binding protein antibody CELF-2 antibody celf2 antibody CELF2_HUMAN antibody CUG BP2 antibody CUG triplet repeat RNA-binding protein 2 antibody CUG-BP- and ETR-3-like factor 2 antibody CUG-BP2 antibody CUGBP Elav like family member 2 antibody CUGBP Elav-like family member 2 antibody CUGBP2 antibody dJ323N1.1 antibody elav type RNA binding protein antibody ELAV-type RNA-binding protein 3 antibody ETR 3 antibody ETR-3 antibody ETR3 antibody HGNC:2550 antibody hNAPOR antibody NAPOR 2 antibody NAPOR antibody Neuroblastoma apoptosis-related RNA-binding protein antibody Neuroplastoma apoptosis related RNA binding protein 3 antibody RNA binding protein BRUNOL3 antibody RNA-binding protein BRUNOL-3 antibody

Abbreviation

CELF-2,CUG-BP2,ETR-3,hNAPOR

Swiss Prot

O95319 Human, Q9Z0H4 Mouse, Q792H5 Rat

Cellular Locus

Nucleus. Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to Human CUGBP Elav-like family member 2 aa450-508 / 508.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell

Positive Control

PC-3M cell lysate, Jurkat cell lysate, THP-1 cell lysate, mouse brain tissue lysate, rat brain tissue lysate, rat cerebellum tissue lysate, Hela, MCF-7, SHG-44.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IF-Cell: 1:50-1:200

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 54 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No