Cathepsin B Rabbit Polyclonal Antibody

About this product

Cathepsin B belongs to a family of lysosomal cysteine proteases known as the cysteine cathepsins and plays an important role in intracellular proteolysis. In humans, cathepsin B is encoded by the CTSB gene. Cathepsin B is upregulated in certain cancers, in pre-malignant lesions, and in various other pathological conditions. Cathepsin B may enhance the activity of other proteases, including matrix metalloproteinase, urokinase (serine protease urokinase plasminogen activator), and cathepsin D, and thus it has an essential position for the proteolysis of extracellular matrix components, intercellular communication disruption, and reduced protease inhibitor expression. It is also involved in autophagy and catabolism, which is advantageous in tumor malignancy, and it is possibly involved in specific immune resistance. Additionally, it was recently determined to have minor ligase activity with the ability to attach peptide fragments via an amide bond.

Specifications

Catalog number

R1407-1

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Amyloid precursor protein secretase antibody APP secretase antibody APPS antibody CATB_HUMAN antibody Cathepsin B heavy chain antibody Cathepsin B1 antibody CathepsinB antibody CPSB antibody CTSB antibody cysteine protease antibody OTTHUMP00000116009 antibody OTTHUMP00000229510 antibody OTTHUMP00000229511 antibody OTTHUMP00000229512 antibody OTTHUMP00000229514 antibody OTTHUMP00000229515 antibody OTTHUMP00000229516 antibody Preprocathepsin B antibody

Abbreviation

APPS

Swiss Prot

P07858 Human

Cellular Locus

Secreted

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human Cathepsin B C-terminal aa 290-339 339.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell

Positive Control

SW480 cell lysate, A549 cell lysate, Hela.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IF-Cell: 1:200

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 38 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No