AKR7A2 Rabbit Polyclonal Antibody

About this product

Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants.

Specifications

Catalog number

R1408-3

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

AFAR antibody AFAR1 antibody AFB1 aldehyde reductase 1 antibody AFB1 AR1 antibody AFB1-AR 1 antibody AFB1AR1 antibody Aflatoxin aldehyde reductase antibody Aflatoxin B1 aldehyde reductase member 2 antibody Aflatoxin beta1 aldehyde reductase antibody Aiar antibody AKR7 antibody Akr7a2 antibody Aldo keto reductase family 7 antibody Aldo keto reductase family 7 member A2 aflatoxin aldehyde reductase antibody Aldo keto reductase family 7 member A2 antibody Aldo keto reductase family 7, member A2 (aflatoxin aldehyde reductase) antibody Aldoketoreductase 7 antibody ARK72_HUMAN antibody SSA reductase antibody Succinic semialdehyde reductase antibody

Abbreviation

AFB1-AR 1,SSA reductase

Swiss Prot

O43488 Human, Q8CG76 Mouse, Q8CG45 Rat

Cellular Locus

Mitochondrion, Golgi apparatus, Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to Human AKR7A2 aa 101-150 / 359.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell

Positive Control

293T cell lysate, A431 cell lysate, Jurkat cell lysate, mouse liver tissue lysate, rat liver tissue lysate, human liver tissue lysate, Hela.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:2,000 ;IF-Cell: 1:200

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 40 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No