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Product details
Catalog number R1408-4
Price for R1408-4
Size / count 100 µL
Lamin B2 is a protein that in humans is encoded by the LMNB2 gene. It is the second of two type B nuclear lamins, and it is associated with laminopathies. Model organisms have been used in the study of Lamin B2 function. A conditional knockout mouse line, called Lmnb2tm1a (KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on mutant mice and four significant abnormalities were observed. No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice. Male heterozygotes displayed increased circulating creatinine levels and an increased susceptibility to Salmonella infection.
The catalog number for LMNB2 Rabbit Polyclonal Antibody is R1408-4.
LMNB2 Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.
LMNB2 Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.
Lamin B2 is a protein that in humans is encoded by the LMNB2 gene. It is the second of two type B nuclear lamins, and it is associated with laminopathies. Model organisms have been used in the study of Lamin B2 function. A conditional knockout mouse line, called Lmnb2tm1a (KOMP)Wtsi was generated as
Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.
Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.
We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.
