PSD95 Rabbit Polyclonal Antibody

About this product

PSD-95 is a member of the membrane-associated guanylate kinase (MAGUK) family. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the?clustering of receptors, ion channels, and associated signaling proteins.PSD-95 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density ofneurons,and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin,NMDA receptors,AMPA receptors, and potassium channels.It plays an important role in synaptic plasticity and the stabilization of synaptic changes during?long-term potentiation.

Specifications

Catalog number

R1508-4

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Discs large homolog 4 antibody Disks large homolog 4 antibody DLG 4 antibody Dlg4 antibody DLG4_HUMAN antibody FLJ97752 antibody FLJ98574 antibody Human post synaptic density protein 95 antibody Post synaptic density protein 95 antibody Postsynaptic density protein 95 antibody PSD 95 antibody PSD-95 antibody PSD95 antibody SAP 90 antibody SAP-90 antibody SAP90 antibody Synapse associated protein 90 antibody Synapse-associated protein 90 antibody Tax interaction protein 15 antibody

Abbreviation

PSD-95,SAP-90,SAP90

Swiss Prot

P78352 Human

Cellular Locus

Cell membrane, Cell projection, Cytoplasm, Membrane, Synapse.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within N-terminal human PSD95.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

A172 cell lysate, mouse brain tissue lysate, SHG-44 cell lysate, N2A cell lysate, rat brain tissue, mouse brain tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1000 ;IHC-P: 1:50 ;FC: 1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 80 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No