Caspase-1 Rabbit Polyclonal Antibody — image 1 of 3

Product details

Caspase-1 Rabbit Polyclonal Antibody

Catalog number R1510-22

Price for R1510-22

Size / count 100 µL

About this product

Caspase-1, originally designated ICE (for IL-1 converting enzyme), is a member of the group of caspases with large prodomains. Caspase-1 promotes maturation of interleukin IL-1β and interleukin18 (IL-18) by proteolytic cleavage of precursor forms into biologically active pro-inflamatory cytokines. Active caspase-1, a (p20/p10)2 tetramer, is necessary and sufficient for cleavage of precursor IL-1 as well as for induction of apoptosis in some cell lines. The highly conserved family of caspases mediate many of the morphological and biochemical features of apoptosis, including structural dismantling of cell bodies and nuclei, fragmentation of genomic DNA, destruction of regulatory proteins and propagation of other pro-apoptotic molecules. The human Caspase-1 gene maps to chromosome 2q14 and encodes a cytoplasmic protein expressed in liver, heart, skeletal muscle kidney and testis. Caspase-1 has been implicated in inflammation, septic shock, and other situations such as wound healing and the growth of certain leukemias.

Specifications

Catalog number: R1510-22
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: Caspase1 CASP-1 antibody CASP1 antibody CASP1_HUMAN antibody Caspase1 antibody Caspase 1 antibody Caspase-1 subunit p10 antibody ICE antibody IL-1 beta-converting enzyme antibody IL-1BC antibody IL1 beta converting enzyme antibody IL1B convertase antibody Interleukin 1 beta convertase antibody Interleukin 1B converting enzyme antibody Interleukin-1 beta convertase antibody Interleukin-1 beta-converting enzyme antibody p45 antibody
Abbreviation: CASP-1,IL-1BC,ICE,IL-1 beta-converting enzyme
Swiss Prot: P29466 Human
Cellular Locus: Cytoplasm
Host: Rabbit
Species Reactivity: Human
Immunogen: Synthetic peptide within human Caspase-1 aa 162-205.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: IHC-P, FC
Positive Control: Human spleen tissue, human lung tissue, human liver cancer tissue, Jurkat.
Concentration: 1 mg/mL
Dilution: IHC-P: 1:50-1:200 ;FC: 1:50-1:100
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: 45 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for Caspase-1 Rabbit Polyclonal Antibody?

The catalog number for Caspase-1 Rabbit Polyclonal Antibody is R1510-22.

What sizes are available for Caspase-1 Rabbit Polyclonal Antibody?

Caspase-1 Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is Caspase-1 Rabbit Polyclonal Antibody in stock?

Caspase-1 Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is Caspase-1 Rabbit Polyclonal Antibody used for?

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.

What temperature does this product ship at?

Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.

What is the molecular weight of the target protein?

Molecular weight information, where applicable, is listed on the datasheet under target details, useful for confirming the correct band on western blot.