MCL1 Rabbit Polyclonal Antibody — image 1 of 3

Product details

MCL1 Rabbit Polyclonal Antibody

Catalog number R1510-26

Price for R1510-26

Size / count 100 µL

About this product

B-cell CLL/lymphoma 2 (Bcl-2) blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal. Myeloid cell leukemia 1 (Mcl-1) shares sequence homology with Bcl-2 and further resembles Bcl-2 in that its expression promotes cell viability. p53 and Mcl-1 demonstrate opposing effects on mitochondrial apoptosis by mediating Bcl-2 antagonist killer (Bak) activity. Mcl-1 is an important and specific regulator that is necessary for the homeostasis of early hematopoietic progenitors. Glycogen synthase kinase 3 (GSK3) controls Mcl-1 stability, which has an effect on the regulation of apoptosis by growth factors, PI 3-kinase and AKT. Mice with a deficiency of the Mcl-1 protein show a significant reduction in B and T lymphocytes similar to the effects observed in IL-7- or IL-7R-deficient mice.

Specifications

Catalog number: R1510-26
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: Bcl 2 related protein EAT/mcl1 antibody Bcl-2-like protein 3 antibody Bcl-2-related protein EAT/mcl1 antibody BCL2 related antibody Bcl2-L-3 antibody BCL2L3 antibody EAT antibody Induced myeloid leukemia cell differentiation protein Mcl 1 antibody Induced myeloid leukemia cell differentiation protein Mcl-1 antibody MCL 1 antibody MCL1 antibody MCL1-ES antibody mcl1/EAT antibody MCL1_HUMAN antibody MCL1L antibody MCL1S antibody MGC104264 antibody MGC1839 antibody Myeloid Cell Leukemia 1 antibody Myeloid cell leukemia ES antibody Myeloid cell leukemia sequence 1 antibody Myeloid cell leukemia sequence 1 BCL2 related antibody Myeloid cell leukemia sequence 1 isoform 1 antibody OTTHUMP00000032794 antibody OTTHUMP00000032795 antibody TM antibody
Abbreviation: Bcl2-L-3
Swiss Prot: Q07820 Human, P97287 Mouse
Cellular Locus: Membrane. Cytoplasm. Mitochondrion.
Host: Rabbit
Species Reactivity: Human, Mouse
Immunogen: Synthetic peptide within human MCL1 aa 58-130.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: IF-Cell, IHC-P
Positive Control: HepG2, SK-BR-3, SW480, human colon cancer tissue, human pancreas tissue, mouse prostate tissue.
Concentration: 1 mg/mL
Dilution: IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: 37 / 29 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for MCL1 Rabbit Polyclonal Antibody?

The catalog number for MCL1 Rabbit Polyclonal Antibody is R1510-26.

What sizes are available for MCL1 Rabbit Polyclonal Antibody?

MCL1 Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is MCL1 Rabbit Polyclonal Antibody in stock?

MCL1 Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is MCL1 Rabbit Polyclonal Antibody used for?

What applications has this product been validated for?

Validated applications such as WB, ELISA, IHC, ICC, or FC are listed on the product datasheet. If you need application-specific validation data before ordering, contact our technical support team with the catalogue number.

How do I reconstitute this lyophilized product?

Reconstitution instructions, including the recommended diluent and final concentration, are provided on the datasheet. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles.

What is the recommended incubation time for this antibody?

A suggested incubation time is provided in the recommended protocol on the datasheet, but may need adjusting depending on your sample type and detection system.