IGF2R/M6PR Rabbit Polyclonal Antibody — image 1 of 3

Product details

IGF2R/M6PR Rabbit Polyclonal Antibody

Catalog number R1510-3

Price for R1510-3

Size / count 100 µL

About this product

The mannose 6-phosphate/insulin-like growth factor II receptor, IGF-IIR (also designated M6P/IGF2R), is a ubiquitously expressed integral glycoprotein. By binding glycoproteins through two of its extracytoplasmic domains, IGF-IIR mediates the activation of TGF∫1 (a growth inhibitor), the degradation of IGF-II and the transport of lysosomal enzymes. Subsequently, IGF-IIR can form oligomeric complexes, which increase the affinity of IGF-IIR for lysosomal enzymes. Unlike IGF-IR, IGF-IIR does not potentiate the signaling of IGF-I or IGF-II, which have mitogenic, cell survival and insulin-like effects. Therefore, IGF-IIR is characterized as a tumor suppressor. Furthermore, the IGF-IIR gene is located on chromosome 6q26, which is commonly mutated or deleted in several human cancers.

Specifications

Catalog number: R1510-3
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: 300 kDa mannose 6 phosphate receptor antibody 300 kDa mannose 6-phosphate receptor antibody Cation independent mannose 6 phosphate receptor antibody Cation-independent mannose-6-phosphate receptor antibody CD222 antibody CD222 antigen antibody CI Man 6 P receptor antibody CI Man-6-P receptor antibody CI MPR antibody CI-M6PR antibody CI-MPR antibody CIMPR antibody IGF 2 receptor antibody IGF 2R antibody IGF II receptor antibody IGF-II receptor antibody IGF2 receptor antibody Igf2r antibody Insulin like growth factor 2 receptor antibody Insulin like growth factor II receptor antibody Insulin-like growth factor 2 receptor antibody Insulin-like growth factor II receptor antibody M6P R antibody M6P/IGF2 receptor antibody M6P/IGF2R antibody M6PR antibody mannose 6 phosphate receptor antibody mannose 6 phosphate receptor, cation independent antibody MPR 300 antibody MPR300 antibody MPRI antibody MPRI_HUMAN antibody
Abbreviation: CI Man-6-P receptor,CI-MPR,M6PR,MPR 300,IGF-II receptor,M6P/IGF2R
Swiss Prot: P11717 Human
Cellular Locus: Golgi apparatus membrane, Endosome membrane.
Host: Rabbit
Species Reactivity: Human
Immunogen: Recombinant protein within human IGF2R aa 1750-1950.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: IF-Cell, IHC-P, FC
Positive Control: Hela, SW480, MCF-7, human lung carcinoma tissue, human tonsil tissue.
Concentration: 1 mg/mL
Dilution: IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200;FC: 1:50-1:100
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 274 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for IGF2R/M6PR Rabbit Polyclonal Antibody?

The catalog number for IGF2R/M6PR Rabbit Polyclonal Antibody is R1510-3.

What sizes are available for IGF2R/M6PR Rabbit Polyclonal Antibody?

IGF2R/M6PR Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is IGF2R/M6PR Rabbit Polyclonal Antibody in stock?

IGF2R/M6PR Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is IGF2R/M6PR Rabbit Polyclonal Antibody used for?

Can you help me confirm if this product is right for my specific experiment?

Yes, contact us with details of your sample type, species, and intended application, and our specialists will confirm suitability or suggest an alternative from our supplier network if this isn’t the best fit.

What is the purity of this recombinant protein?

Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.