CCL3 Rabbit Polyclonal Antibody

About this product

Chemokines are members of a superfamily of small inducible, secreted, pro-inflammatory cytokines. Members of the chemokine family exhibit 20 to 50% homology in their predicted amino acid sequences and are divided into four subfamilies. In C-C (or b) subfamily, the first two cysteines are adjacent. C-C chemokines are chemoattractants and activators for monocytes and T cells. C-C subfamily members include macrophage inflammatory protein (MIP)-1α, MIP-1β, MIP-2, MIP-3α, MIP-3β, MIP-4, HCC-1, MIP-5 (or HCC-2), RANTES, MCP-1/2/3 (and the murine homologs JE and MARC), I-309, murine C10 and TCA3. Research has shown that MIP-1β is more selective than MIP-1α, primarily attracting CD4+ T lymphocytes, with a preference for T cells of the naive phenotype. MIP-1α is a more potent lymphocyte chemoattractant than MIP-1β and exhibits a broader range of chemoattractant specificities. It has been suggested that CD8+ T lymphocytes are involved in the control of HIV infection in vivo by the release of HIV-suppressive factors (HIV-SF). MIP-1α has been identified as one of the major HIV-SFs produced by CD8+ T cells, along with MIP-1β and RANTES

Specifications

Catalog number

R1510-9

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

C C motif chemokine 3 antibody CCL 3 antibody CCL3 antibody CCL3_HUMAN antibody Chemokine C C motif ligand 3 antibody G0/G1 switch regulatory protein 19 1 antibody G0/G1 switch regulatory protein 19-1 antibody G0S19 1 antibody G0S19 1 protein antibody Heparin binding chemotaxis protein antibody L2G25B antibody LD78 alpha antibody LD78-alpha (4-69) antibody LD78alpha antibody Macrophage inflammatory protein 1 alpha antibody Macrophage inflammatory protein 1-alpha antibody MIP 1 alpha antibody MIP 1A antibody MIP-1-alpha antibody MIP-1-alpha (4-69) antibody MIP1A antibody PAT 464.1 antibody SCYA 3 antibody SCYA3 antibody SIS alpha antibody SIS beta antibody SIS-beta antibody Small inducible cytokine A3 antibody small inducible cytokine A3 (homologous to mouse Mip-1a) antibody Small-inducible cytokine A3 antibody Tonsillar lymphocyte LD78 alpha protein antibody

Abbreviation

MIP-1-alpha

Swiss Prot

P10147 Human, P10855 Mouse, P50229 Rat

Cellular Locus

Secreted

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within mouse CCL3 aa 43-92 / 92.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC, ELISA

Positive Control

HeLa cell lysate, PANC-1 cell lysate, rat brain tissue lysate, mouse brain tissue lysate, mouse lung tissue lysate, Hela, PANC-1, A549, mouse pancreas tissue, mouse lung tissue, mouse spleen tissue, A549 cell lysate.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 10 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No