SIRT6 Rabbit Polyclonal Antibody — image 1 of 3

Product details

SIRT6 Rabbit Polyclonal Antibody

Catalog number R1511-1

Price for R1511-1

Size / count 100 µL

About this product

The Silent Information Regulator (Sir2) family of genes is a highly conserved group of genes that encode nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases, also known as class III histone deacetylases. The first discovered and best characterized of this family is Saccharomyces cerevisiae Sir2, which is involved in silencing of mating type loci, telomere maintenance, DNA damage response, and cell aging. SirT6, a mammalian homolog of Sir2, is a nuclear, chromatin-associated protein that promotes the normal maintenance of genome integrity mediated by the base excision repair (BER) pathway. The BER pathway repairs single-stranded DNA lesions that arise spontaneously from endogenous alkylation, oxidation, and deamination events. SirT6 deficient mice show increased sensitivity to DNA-damaging agents, including the alkylating agents MMS and H2O2. In addition, these mice show genome instability with increased frequency of fragmented chromosomes, detached centromeres, and gaps. SirT6 may regulate the BER pathway by deacetylating DNA Polβ or other core components of the pathway.

Specifications

Catalog number: R1511-1
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: 2810449N18Rik antibody AI043036 antibody Mono ADP ribosyltransferase sirtuin 6 antibody NAD-dependent protein deacetylase sirtuin-6 antibody Regulatory protein SIR2 homolog 6 antibody Regulatory protein SIR2 homolog antibody SIR2 like 6 antibody SIR2 like protein 6 antibody Sir2 related protein type 6 antibody SIR2-like protein 6 antibody SIR2L6 antibody SIR6_HUMAN antibody SIRT 6 antibody SIRT6 antibody Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) antibody Sirtuin 6 antibody Sirtuin type 6 antibody Sirtuin6 antibody
Abbreviation: SIRT6
Swiss Prot: Q8N6T7 Human
Cellular Locus: Nucleus, cytoplasm
Host: Rabbit
Species Reactivity: Human, Mouse
Immunogen: Synthetic peptide within N-terminal human SIRT6.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: IHC-P, FC
Positive Control: Mouse brain tissue, mouse thymus tissue
Concentration: 1 mg/mL
Dilution: IHC-P: 1:50-1:200 ;FC: 1:50-1:100
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: 39kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for SIRT6 Rabbit Polyclonal Antibody?

The catalog number for SIRT6 Rabbit Polyclonal Antibody is R1511-1.

What sizes are available for SIRT6 Rabbit Polyclonal Antibody?

SIRT6 Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is SIRT6 Rabbit Polyclonal Antibody in stock?

SIRT6 Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is SIRT6 Rabbit Polyclonal Antibody used for?

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.

What is the difference between this product and a similar catalogue number?

Differences typically involve clone, conjugate, host species, or validated applications. Compare the respective datasheets, or contact us with both catalogue numbers for a direct comparison.