HSP47 Rabbit Polyclonal Antibody

About this product

Heat shock protein 47, also known as SERPINH1 is a serpin which serves as a human chaperone protein for collagen. This protein is a member of the serpin superfamily of serine proteinase inhibitors. Its expression is induced by heat shock. HSP47 is expressed by cells present in Endoplasmic Reticulum. These cells synthesize and secrete type I and type II collagen. The protein localizes to the endoplasmic reticulum lumen and binds collagen; thus it is thought to be a molecular chaperone involved in the maturation of collagen molecules. Autoantibodies to this protein have been found in patients with rheumatoid arthritis. Heat shock protein 47 has been shown to interact with collagens I, II, III, IV and V. In the ER, HSP47 interacts with and stabilizes correctly-folded procollagen. Nucleotide polymorphisms may be associated with preterm birth and Osteogenesis Imperfecta type X. Serpin-H1 is up-regulated in several cancers including squamous cell carcinoma, breast and prostate carcinomas. Expression in tumors drives malignant growth and invasion by enhancing deposition of extracellular matrix proteins.

Specifications

Catalog number

R1511-11

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

47 kDa heat shock protein antibody 47 kDa heat shock protein precursor antibody Arsenic transactivated protein 3 antibody Arsenic-transactivated protein 3 antibody AsTP 3 antibody AsTP3 antibody CBP 1 antibody CBP 2 antibody CBP1 antibody CBP2 antibody Cell proliferation-inducing gene 14 protein antibody Collagen binding protein 1 antibody Collagen binding protein 2 antibody Collagen binding protein antibody Collagen-binding protein 2 antibody Collagen-binding protein antibody Colligen antibody Colligin 1 antibody Colligin 2 antibody Colligin antibody colligin-1 antibody colligin-2 antibody gp46 antibody Heat shock protein 47 antibody Heat-shock protein 47 antibody HGNC 1547 antibody Hsp 47 antibody J6 antibody OI10 antibody PIG 14 antibody PIG14 antibody PPROM antibody Proliferation inducing gene 14 antibody Proliferation inducing gene 14 protein antibody RA A47 antibody RA-A47 antibody Rheumatoid arthritis antigen A 47 antibody rheumatoid arthritis antigen A-47 antibody Rheumatoid arthritis related antigen RA A47 antibody Rheumatoid arthritis-related antigen RA-A47 antibody serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) antibody serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 2, (collagen-binding protein 2) antibody Serine or cysteine proteinase inhibitor clade H member 1 antibody Serine or cysteine proteinase inhibitor clade H member 2 antibody SERPH_HUMAN antibody Serpin H1 antibody Serpin peptidase inhibitor clade H member 1 antibody serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) antibody Serpin peptidase inhibitor, clade H, member 1 antibody SERPINH1 antibody SERPINH2 antibody

Abbreviation

Serpin H1 47 kDa heat shock protein Arsenic-transactivated protein 3 AsTP3 Cell proliferation-inducing gene 14 protein Collagen-binding protein Colligin Rheumatoid arthritis-related antigen RA-A47 SERPINH1 CBP1, CBP2, HSP47, SERPINH2

Swiss Prot

P50454 Human, P19324 Mouse, P29457 Rat

Cellular Locus

Endoplasmic reticulum.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human HSP47 aa 72-318 / 418.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P

Positive Control

Rat placenta tissue lysate, Siha cell lysate, NIH/3T3 cell lysate, human placenta tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:100-1:500

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

46 kDa.

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No