SIRT3 Rabbit Polyclonal Antibody

About this product

The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and are involved in diverse processes, including transcriptional regulation, cell cycle progression, DNA-damage repair and aging. In S. cerevisiae, Sir2p deacetylates histones in an NAD-dependent manner, which regulates silencing at the telomeric, rDNA and silent mating-type loci. Sir2p is the founding member of a large family, designated sirtuins, which contain a conserved catalytic domain. The human homologues, which include SIRT1-7, are divided into four main branches: SIRT1-3 are class I, SIRT4 is class II, SIRT5 is class III and SIRT6-7 are class IV. SIRT3 is a NAD-dependent deacetylase that contains one deacetylase sirtuin-type domain. The SIRT3 protein is widely expressed and localizes to the mitochondira where it is processed by mitochondrial processing peptidase (MPP) to yield a final product. This processing is most-likely necessary for its enzymatic activity.

Specifications

Catalog number

R1511-3

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

hSIRT 3 antibody hSIRT3 antibody Mitochondrial nicotinamide adenine dinucleotide dependent deacetylase antibody NAD dependent deacetylase sirtuin 3 mitochondrial antibody NAD-dependent protein deacetylase sirtuin-3, mitochondrial antibody Regulatory protein SIR2 homolog 3 antibody Silent mating type information regulation 2 S.cerevisiae homolog 3 antibody Sir 2 like 3 antibody SIR 2 like protein 3 antibody SIR 3 antibody SIR2 L3 antibody Sir2 like 3 antibody SIR2 like protein 3 antibody SIR2-like protein 3 antibody SIR2L3 antibody SIR3_HUMAN antibody SIRT 3 antibody SIRT3 antibody Sirtuin 3 antibody Sirtuin silent mating type information regulation 2 homolog 3 (S. cerevisiae) antibody Sirtuin type 3 antibody Sirtuin3 antibody

Abbreviation

hSIRT3

Swiss Prot

Q9NTG7 Human, Q8R104 Mouse,

Cellular Locus

Mitochondrion matrix

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human SIRT3 aa 51-399 / 399.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB

Positive Control

PANC-1 cell lysate, HepG2 cell lysate, Mouse liver tissue lysate, Rat liver tissue lysate.

Concentration

1 mg/mL

Dilution

WB: 1:2,000

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 44 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No