Bad Rabbit Polyclonal Antibody — image 1 of 3

Product details

Bad Rabbit Polyclonal Antibody

Catalog number R1511-32

Price for R1511-32

Size / count 100 µL

About this product

The Bcl-2 family of proteins is characterized by its ability to modulate cell death (apoptosis) under a broad range of physiologic conditions. Bcl-2 and several related proteins function to inhibit apoptosis while other members of the Bcl-2 family, such as Bax and Bak, enhance cell death under various conditions. For instance, Bcl-xL represses cell death, while its shorter form, Bcl-xS, promotes apoptosis. A protein designated Bad exhibits homology to Bcl-2 limited to the BH1 and BH2 domains. Bad functions to dimerize with Bcl-xL and with Bcl-2, but not with Bax, Bcl-xS, Mcl-1, A1 or itself. In mammalian cells, Bad binds with greater affinity to Bcl-xL than to Bcl-2 and reverses the death repressor activity of Bcl-xL but not Bcl-2. Dimerization of Bad with Bcl-xL results in displacement of Bax from Bcl-xL:Bax complexes thereby causing restoration of Bax-mediated apoptosis.

Specifications

Catalog number: R1511-32
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: AI325008 antibody BAD antibody BAD_HUMAN antibody BBC 2 antibody BBC2 antibody BBC6 antibody Bcl 2 Antagonist of Cell Death antibody Bcl 2 Binding Component 6 antibody BCL X / BCL 2 Binding Protein antibody BCL X Binding Protein antibody Bcl XL/Bcl 2 Associated Death Promoter antibody Bcl-2-binding component 6 antibody Bcl-2-like protein 8 antibody Bcl-XL/Bcl-2-associated death promoter antibody Bcl2 antagonist of cell death antibody BCL2 antagonist of cell death protein antibody BCL2 associated agonist of cell death antibody Bcl2 Associated Death Promoter antibody BCL2 binding component 6 antibody BCL2 binding protein antibody Bcl2 Like 8 Protein antibody Bcl2-L-8 antibody BCL2L8 antibody Proapoptotic BH3 Only Protein antibody
Abbreviation: BAD, Bcl2-L-8
Swiss Prot: Q92934 Human
Cellular Locus: Mitochondrion outer membrane, Cytoplasm
Host: Rabbit
Species Reactivity: Human
Immunogen: Synthetic peptide within Human Bad aa 1-50 / 168.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: WB, IF-Cell, IHC-P, FC
Positive Control: HepG2, SK-BR-3, SW480, human breast carcinoma tissue, MCF-7
Concentration: 1 mg/mL
Dilution: IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200;FC: 1:50-1:200
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for Bad Rabbit Polyclonal Antibody?

The catalog number for Bad Rabbit Polyclonal Antibody is R1511-32.

What sizes are available for Bad Rabbit Polyclonal Antibody?

Bad Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is Bad Rabbit Polyclonal Antibody in stock?

Bad Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is Bad Rabbit Polyclonal Antibody used for?

What is the recommended storage temperature after reconstitution?

Post-reconstitution storage guidance is listed on the datasheet, typically requiring aliquoting and storage at -20°C or -80°C to preserve activity.

Can this product be used in multiplex assays?

Multiplex compatibility depends on the specific product and detection panel. Contact our technical support team with details of your multiplex system for guidance before ordering.

What happens if this product doesn’t perform as expected in my experiment?

Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.