B7-H4 (VTCN1) Rabbit Polyclonal Antibody

About this product

T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory proteins. One such protein, B7-H4 (B7-homolog 4, also designated VTCN1), belongs to the B7 Immunoglobulin superfamily of ligand-lymphocyte interacting proteins. Expressed primarily on the membrane of lymphoid cells, B7-H4 is an immunoinhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of the B7-H4 protein is associated with certain malignancies, including ovarian and breast cancer, as its interaction with T cells supresses tumor-associated immunity. Current research suggests that, similar to Mucin 16 (CA125), B7-H4 may be a useful biomarker for the early detection of ovarian cancer.

Specifications

Catalog number

R1512-1

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

B7 family member, H4 antibody B7 H4 antibody B7 homolog 4 antibody B7 superfamily member 1 antibody B7 superfamily, member 1 antibody B7-H4 antibody B7h.5 antibody B7h4 antibody B7S1 antibody B7x antibody BC032925 antibody Immune costimulatory protein B7-H4 antibody Immune costimulatory protein B7H4 antibody MGC41287 antibody PRO1291 antibody Protein B7S1 antibody RP11 229A19.4 antibody T cell costimulatory molecule B7x antibody T-cell costimulatory molecule B7x antibody V set domain-containing T cell activation inhibitor 1 antibody V-set domain-containing T-cell activation inhibitor 1 antibody VCTN1 antibody Vtcn1 antibody VTCN1_HUMAN antibody

Abbreviation

B7-H4

Swiss Prot

Q7Z7D3 Human, Q7TSP5 Mouse

Cellular Locus

Cell membrane.

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant protein within Human B7-H4 aa 65-226 / 282.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

SK-Br-3 cell lysate, human liver tissue lysate, mouse testis tissue lysate, mouse spleen tissue lysate, Hela, MCF-7, SK-Br-3, human tonsil tissue, human lung cancer tissue, Jurkat.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200;FC: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 31 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No