IMP3 Rabbit Polyclonal Antibody

About this product

IGF-II mRNA-binding proteins (IMPs) bind RNA and influence RNA synthesis and metabolism. IMP-1, also known as coding region determinant-binding protein/insulin-like growth factor II mRNA-binding protein (CRD-BP) and VICKZ1; IMP-2 (IMP2, VICKZ2, p62); and IMP-3 (KOC1, VICKZ3) contain a unique combination of RNA recognition motifs and four hnRNP K homology domains. IMP-1 is abundant in embryonal tissues and is expressed in 81% of colon cancers, 73% of sarcomas and 58.5% of breast cancers. It recognizes c-Myc, IGF-II and t mRNAs, and H19 RNA, and plays a major role in proliferation of K-562 cells by an IGF-II-dependent mechanism. IMP-2 binds the 5' UTR of IGF-II mRNA and influences tumor cell growth, in which IMP-2 is associated with apoptosis induced by tretinoin. IMP-3 knockdown by RNA interference decreases levels of IGF-II protein without affecting IGF-II, c-Myc, or β Actin mRNA and H19 RNA levels. IMP-3 is a marker for carcinomas and high-grade dysplastic lesions of pancreatic ductal epithelium.

Specifications

Catalog number

R1512-10

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Cancer/testis antigen 98 antibody CT98 antibody DKFZp686F1078 antibody hKOC antibody IF2B3_HUMAN antibody IGF II mRNA binding protein 3 antibody IGF-II mRNA-binding protein 3 antibody IGF2 mRNA binding protein 3 antibody IGF2 mRNA-binding protein 3 antibody IGF2BP3 antibody IMP 3 antibody IMP-3 antibody Insulin like growth factor 2 mRNA binding protein 3 antibody Insulin-like growth factor 2 mRNA-binding protein 3 antibody KH domain containing protein overexpressed in cancer antibody KH domain-containing protein overexpressed in cancer antibody KOC 1 antibody KOC1 antibody VICKZ 3 antibody VICKZ family member 3 antibody VICKZ3 antibody

Abbreviation

IGF2 mRNA-binding protein 3, IMP-3, hKOC, IMP3, KOC1, VICKZ3

Swiss Prot

O00425 Human, Q9CPN8 Mouse,

Cellular Locus

Nucleus, Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human IMP-3 aa 352-579 / 579.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

HeLa cell lysate, 293T cell lysate, MCF7 cell lysate, THP-1 cell lysate, rat brain tissue, human placental tissue, mouse testis tissue, mouse brain tissue, HepG2.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:2,000 ;IHC-P: 1:50-1:400 ;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 64 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No