AKR1C1 Rabbit Polyclonal Antibody

About this product

Human liver contains isoforms of dihydrodiol dehydrogenase (DD1, DD2, DD3 and DD4), which belong to the aldo-oxo reductase/aldo-keto reductase (AKR) superfamily, have 20α- or 3α-hydroxysteroid dehydrogenase (HSD) activity. DD1 is also designated AKR1C1, DDH or DDH1, while DD2 also can be designated AKR1C2, dDD, BABP or DDH2. AKR1C3 and 3α-HSD are alternate designations for human DD3 (which is referred to as AKR1C18 in rodents), while DD4 also can be called AKR1C4, CD, CHDR or AKR1C6 (in rodents). DD1 and DD2 are 20α-HSDs, whereas DD3 and DD4 are the 3α-HSDs. The multiple human cytosolic dihydrodiol dehydrogenases are involved in the metabolism of xenobiotics, such as polycyclic aromatic hydrocarbons, pesticides and steroid hormones, and are responsible for the reduction of ketone-containing drugs by using NADH or NADPH as a cofactor. The 20α-HSD catalyzes the reaction of progesterone to the inactive form 20α-hydroxyprogesterone. The 3α-HSD is a cytosolic, monomeric, NADPH-dependent oxidoreductase that reduces 3-keto-5-dihydrosteroids to their tetrahydro products. DD1 and DD2 are ubiquitously expressed, whereas DD4 mRNA is restricted to the liver. DD3 is a unique enzyme that can specifically catalyze the dehydrogenation of trans-benzenedihydrodiol and trans-naphthalenedihydrodiol.

Specifications

Catalog number

R1512-11

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

2-dihydrobenzene-1 antibody 2-diol dehydrogenase antibody 20 alpha (3 alpha) hydroxysteroid dehydrogenase antibody 20 ALPHA HSD antibody 20 alpha hydroxysteroid dehydrogenase antibody 20-alpha-HSD antibody 20-alpha-hydroxysteroid dehydrogenase antibody 20ALPHAHSD antibody 2ALPHAHSD antibody AK1C1 antibody AK1C1_HUMAN antibody AKR1C1 antibody Aldo keto reductase family 1 member C1 antibody aldo-keto reductase C antibody Aldo-keto reductase family 1 member C1 antibody Aldo-keto reductase family, 1 member 1 antibody C9 antibody Chlordecone reductase homolog antibody Chlordecone reductase homolog HAKRC antibody DD1 antibody DD1/DD2 antibody DDH antibody DDH1 antibody Dihydrodiol dehydrogenase 1 antibody Dihydrodiol dehydrogenase 1/2 antibody dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase antibody dihydrodiol dehydrogenase isoform DD1 antibody Dihydrodiol dehydrogenase, type 1 antibody H37 antibody HAKRC antibody HBAB antibody Hepatic dihydrodiol dehydrogenase antibody High affinity hepatic bile acid-binding protein antibody High-affinity hepatic bile acid-binding protein antibody Indanol dehydrogenase antibody MBAB antibody MGC8954 antibody Trans-1 antibody Trans-1,2 dihydrobenzene 1,2 diol dehydrogenase antibody Type II 3 alpha hydroxysteroid dehydrogenase antibody

Abbreviation

20-alpha-HSD, DD1/DD2, HBAB

Swiss Prot

Q04828 Human

Cellular Locus

Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant protein within Human AKR1C1 aa 180-323 / 323.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

Mouse testes tissue lysate, SW480 cell lysate, human liver cancer tissue, mouse kidney tissue, mouse stomach tissue, HepG2.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 37 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No