RON Rabbit Polyclonal Antibody

About this product

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.

Specifications

Catalog number

R1512-2

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

c met related tyrosine kinase antibody CD136 antibody CD136 antigen antibodyCDw136 antibody Macrophage stimulating 1 receptor (c met related tyrosine kinase) antibody Macrophage stimulating 1 receptor antibody Macrophage stimulating protein receptor alpha chain antibody MACROPHAGE STIMULATING PROTEIN RECEPTOR antibody Macrophage stimulating protein receptor beta chain antibody Macrophage-Stimulating 1 Receptor (MST1R) antibody Macrophage-stimulating protein receptor beta chain antibody MSP receptor antibody Mst1r antibody MST1R variant RON30 antibody MST1R variant RON62 antibody NPCA3 antibody p185 RON antibody p185-Ron antibody Protein-tyrosine kinase 8 antibody PTK 8 antibody ptk8 antibody PTK8 protein tyrosine kinase 8 antibody Recepteur d’origine nantais (RON) antibody RON antibody RON protein tyrosine kinase antibody RON variant E2E3 antibody RON_HUMAN antibody Soluble RON variant 1 antibody Soluble RON variant 2 antibody Soluble RON variant 3 antibody Soluble RON variant 4 antibody Stem cell derived tyrosine kinase antibody

Abbreviation

MSP receptor, MST1R, PTK8, RON

Swiss Prot

Q04912 Human

Cellular Locus

Membrane.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within C-terminal human RON.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

IF-Cell, IHC-P

Positive Control

A549, Ags, SW480, human breast tissue, human breast cancer tissue, human stomach cancer tissue.

Concentration

1 mg/mL

Dilution

IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 152 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No