CXCR7 Rabbit Polyclonal Antibody

About this product

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.

Specifications

Catalog number

R1512-3

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

ACKR3 antibody atypical chemokine receptor 3 antibody C X C chemokine receptor type 7 antibody C-X-C chemokine receptor type 7 antibody Chemokine (C-X-C motif) receptor 7 antibody Chemokine C X C motif receptor 7 antibody Chemokine orphan receptor 1 antibody CMKOR1 antibody CXC R7 antibody CXC-R7 antibody CXCR 7 antibody CXCR-7 antibody CXCR7 antibody CXCR7_HUMAN antibody G protein coupled receptor 159 antibody G protein coupled receptor antibody G protein coupled receptor RDC1 homolog antibody G-protein coupled receptor 159 antibody G-protein coupled receptor RDC1 homolog antibody GPCR RDC1 antibody GPR159 antibody GPRN1 antibody RDC 1 antibody RDC-1 antibody RDC1 antibody

Abbreviation

Atypical chemokine receptor 3 C-X-C chemokine receptor type 7 CXC-R7 CXCR-7 Chemokine orphan receptor 1 G-protein coupled receptor 159 G-protein coupled receptor RDC1 homolog RDC-1

Swiss Prot

P25106 Human

Cellular Locus

Cell membrane, Cytoplasm, Endosome, Membrane

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within C terminal human CXCR7.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, FC

Positive Control

Hela cell lysate, MCF-7 cell lysate, Jurkat cell lysate, Hela, HUVEC, MCF-7.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IF-Cell: 1:50-1:200 ;FC: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 41 kDa.

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No