HLA Class 1 ABC Rabbit Polyclonal Antibody

About this product

Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells. May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity. Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells. Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome or via endopeptidase IDE/insulin-degrading enzyme. Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9.

Specifications

Catalog number

R1601-11

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

HLA A antibody HLA B antibody HLA C antibody HLA class 1 A antibody HLA class 1 B antibody HLA class 1 C antibody Major histocompatibility complex, class I, A + B + C antibody MHC class I HLA A antibody MHC class I HLA B antibody MHC class I HLA C antibody MHC HLA ABC antibody

Abbreviation

HLA-A, HLAA, HLA-B, HLAB, HLA-C, HLAC

Swiss Prot

P30443 Human, P01889 Human, P30499 Human

Cellular Locus

Cell membrane, Endoplasmic reticulum membrane.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within Human HLA Class 1 ABC aa 125-325 / 362.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

Hela cell lysate, human colon cancer tissue, human prostate tissue, Jurkat.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:200-1:500 ;FC: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 41 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

No