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Product details

IREB2 Rabbit Polyclonal Antibody

Catalog number R1706-12

Price for R1706-12

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Size / count 100 µL

About this product

Iron metabolism is essential for sustaining mammalian homeostasis. Iron uptake and distribution is a highly regulated process in mammalian cells that is monitored by two iron sensing proteins: IRP-1 and -2 (iron regulatory protein-1 and -2), also known as iron responsive element-binding protein-1 and -2 (IRE-BP-1 and -2) or aconitase 1 and 2. IRP-1 and IRP-2 are important soluble regulatory factors that mediate iron uptake and storage in mammalian cells. They are capable of either repressing translation or enhancing mRNA stability by associating with stem-loop motifs known as iron-responsive elements (IREs). IRPs respond to stress mediators, iron concentration and signaling factors, including nitrogen monoxide, cytokines and hydrogen peroxide.

Specifications

Catalog number
R1706-12
Size / count
100 µL
Dry ice
No
Hazardous
No
Discontinued
No
CAS Number
9007-83-4
Product Name Alternative
ACO3 antibody FLJ23381 antibody IRE BP2 antibody IRE-BP 2 antibody IREB 2 antibody IREB2 antibody IREB2_HUMAN antibody Iron regulatory protein 2 antibody iron responsive element binding protein 2 antibody Iron-responsive element-binding protein 2 antibody IRP 2 antibody IRP2 antibody IRP2AD antibody OTTHUMP00000185022 antibody
Abbreviation
IRE-BP 2, IRP2, IREB2
Swiss Prot
P48200 Human, Q811J3 Mouse, Q62751 Rat
Cellular Locus
Cytoplasm.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within Human IREB2 aa 17-301 / 963.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
K562, mouse kidney tissue lysate, rat skin tissue lysate, 293T, A549, HepG2, human kidney tissue, human placenta tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:1000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 105/38 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No

Frequently Asked Questions

What is the catalog number for IREB2 Rabbit Polyclonal Antibody?

The catalog number for IREB2 Rabbit Polyclonal Antibody is R1706-12.

What sizes are available for IREB2 Rabbit Polyclonal Antibody?

IREB2 Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is IREB2 Rabbit Polyclonal Antibody in stock?

IREB2 Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is IREB2 Rabbit Polyclonal Antibody used for?

Iron metabolism is essential for sustaining mammalian homeostasis. Iron uptake and distribution is a highly regulated process in mammalian cells that is monitored by two iron sensing proteins: IRP-1 and -2 (iron regulatory protein-1 and -2), also known as iron responsive element-binding protein-1 an

What is the recommended storage temperature after reconstitution?

Post-reconstitution storage guidance is listed on the datasheet, typically requiring aliquoting and storage at -20°C or -80°C to preserve activity.

Can this product be used in multiplex assays?

Multiplex compatibility depends on the specific product and detection panel. Contact our technical support team with details of your multiplex system for guidance before ordering.

What happens if this product doesn’t perform as expected in my experiment?

Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.

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