Anti-EGFR Antibody [SZ40-19] — image 1 of 2

Product details

Anti-EGFR Antibody [SZ40-19]

Catalog number ET1603-37TR

Price for ET1603-37TR

Size / count 20 µL

About this product

The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Exons in the EGFR gene product are frequently either deleted or duplicated to produce deletion mutants (DM) or tandem duplication mutants (TDM), respectively, which are detected at various molecular weights. EGFR binds several ligands, including epidermal growth factor (EGF), transforming growth factor α (TGFα), Amphiregulin and heparin binding-EGF (HB-EGF). Ligand binding promotes the internalization of EGFR via Clathrin-coated pits and its subsequent degradation in response to its intrinsic tyrosine kinase. EGFR is involved in organ morphogenesis and maintenance and repair of tissues, but upregulation of EGFR is associated with tumor progression. The oncogenic effects of EGFR include initiation of DNA synthesis, enhanced cell growth, invasion and metastasis. Abrogation of EGFR results in cell cycle arrest, apoptosis or dedifferentiation of cancer cells, suggesting that EGFR may be an effective therapeutic target.

Specifications

Catalog number: ET1603-37TR
Size / count: 20 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: Avian erythroblastic leukemia viral (v erb b) oncogene homolog antibody Cell growth inhibiting protein 40 antibody Cell proliferation inducing protein 61 antibody EGF R antibody EGFR antibody EGFR_HUMAN antibody Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog) antibody Epidermal growth factor receptor (erythroblastic leukemia viral (v erb b) oncogene homolog avian) antibody Epidermal growth factor receptor antibody erb-b2 receptor tyrosine kinase 1 antibody ERBB antibody ERBB1 antibody Errp antibody HER1 antibody mENA antibody NISBD2 antibody Oncogen ERBB antibody PIG61 antibody Proto-oncogene c-ErbB-1 antibody Receptor tyrosine protein kinase ErbB 1 antibody Receptor tyrosine-protein kinase ErbB-1 antibody SA7 antibody Species antigen 7 antibody Urogastrone antibody v-erb-b Avian erythroblastic leukemia viral oncogen homolog antibody wa2 antibody Wa5 antibody
Abbreviation: EGFR
Swiss Prot: P00533 Human; Q01279 Mouse
Cellular Locus: Secreted and Cell membrane.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein within human EGFR aa 1175-1210/1210.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IF-Cell, IF-Tissue, IHC-P, IP, FC
Positive Control: HeLa cell lysate, A431 cell lysate, MDA-MB-468 cell lysate, A431, Hela, HepG2, human tonsil tissue, human kidney tissue, mouse liver tissue, mouse skin tissue, mouse kidney tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:2,000 ;IF-Cell: 1:500 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:200 ;IP: 1:10-1:50 ;FC: 1:1,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted 134 kDa, observed 150 kDa.
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: True

Frequently Asked Questions

What is the catalog number for Anti-EGFR Antibody [SZ40-19]?

The catalog number for Anti-EGFR Antibody [SZ40-19] is ET1603-37TR.

What sizes are available for Anti-EGFR Antibody [SZ40-19]?

Anti-EGFR Antibody [SZ40-19] is available in the following size(s): 20 µL.

Is Anti-EGFR Antibody [SZ40-19] in stock?

Anti-EGFR Antibody [SZ40-19] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Anti-EGFR Antibody [SZ40-19] used for?

What happens if this product doesn’t perform as expected in my experiment?

Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.

Is this product classed as hazardous or restricted for shipping?

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Can you help me confirm if this product is right for my specific experiment?

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