Anti-Phospho-STAT3 (Tyr705) Antibody [SZ43-01] — image 1 of 2

Product details

Anti-Phospho-STAT3 (Tyr705) Antibody [SZ43-01]

Catalog number ET1603-40TR

Price for ET1603-40TR

Size / count 20 µL

About this product

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Acts as a regulator of inflammatory response by regulating differentiation of naive CD4+ T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1. Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation. May play an apoptotic role by transctivating BIRC5 expression under LEP activation. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion.

Specifications

Catalog number: ET1603-40TR
Size / count: 20 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: 1110034C02Rik antibody Acute Phase Response Factor antibody Acute-phase response factor antibody ADMIO antibody APRF antibody AW109958 antibody DNA binding protein APRF antibody FLJ20882 antibody HIES antibody MGC16063 antibody Signal transducer and activator of transcription 3 (acute phase response factor) antibody Signal transducer and activator of transcription 3 antibody STAT 3 antibody Stat3 antibody STAT3_HUMAN antibody
Abbreviation: STAT3
Swiss Prot: P40763 Human; P42227 Mouse; P52631 Rat
Cellular Locus: Cytoplasm, Nucleus.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Tyr705 of human STAT3.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IHC-P, IP
Positive Control: HeLa treated with 50ng/mL IFN alpha 1 for 30 minutes whole cell lysate, Jurkat treated with 50ng/mL IFN alpha 1 for 30 minutes whole cell lysate, A431 treated with 100ng/mL EGF for 30 minutes whole cell lysate, human lung tissue, Hela cell lysate, SK-Br-3 cell lysate, human kidney tissue, mouse skeletal muscle tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:5,000 ;IHC-P: 1:50-1:200 ;IP: Use at an assay dependent concentration.
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 88 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: True

Frequently Asked Questions

What is the catalog number for Anti-Phospho-STAT3 (Tyr705) Antibody [SZ43-01]?

The catalog number for Anti-Phospho-STAT3 (Tyr705) Antibody [SZ43-01] is ET1603-40TR.

What sizes are available for Anti-Phospho-STAT3 (Tyr705) Antibody [SZ43-01]?

Anti-Phospho-STAT3 (Tyr705) Antibody [SZ43-01] is available in the following size(s): 20 µL.

Is Anti-Phospho-STAT3 (Tyr705) Antibody [SZ43-01] in stock?

Anti-Phospho-STAT3 (Tyr705) Antibody [SZ43-01] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Anti-Phospho-STAT3 (Tyr705) Antibody [SZ43-01] used for?

Does this product need any special customs documentation to be imported to my country?

If you’re outside the EU, UK, or USA, you’re responsible for customs clearance and any related taxes or fees. We provide the standard import documents, such as the Commercial Invoice, Packing List, and Airway Bill, in advance, so let us know early if your customs office needs anything additional for this specific product.

What buffer is this product supplied in?

The formulation or storage buffer is listed on the product datasheet. If you require a carrier-free or custom formulation, contact us before ordering, as this may involve a made-to-order production timeline.

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.