Anti-Cleaved PARP Antibody [SU0314] — image 1 of 2

Product details

Anti-Cleaved PARP Antibody [SU0314]

Catalog number ET1608-10TR

Price for ET1608-10TR

Size / count 20 µL

About this product

Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes such as DNA repair, genomic stability, and programmed cell death. The main role of PARP (found in the cell nucleus) is to detect and initiate an immediate cellular response to metabolic, chemical, or radiation-induced single-strand DNA breaks (SSB) by signaling the enzymatic machinery involved in the SSB repair. Once PARP detects a SSB, it binds to the DNA, undergoes a structural change, and begins the synthesis of a polymeric adenosine diphosphate ribose (poly (ADP-ribose) or PAR) chain, which acts as a signal for the other DNA-repairing enzymes. Target enzymes include DNA ligase III (LigIII), DNA polymerase beta (polβ), and scaffolding proteins such as X-ray cross-complementing gene 1 (XRCC1). After repairing, the PAR chains are degraded via Poly (ADP-ribose) glycohydrolase (PARG). PARP enzymes are essential in a number of cellular functions, including expression of inflammatory genes: PARP1 is required for the induction of ICAM-1 gene expression by cardiac myocytes and smooth muscle cells, in response to TNF.

Specifications

Catalog number: ET1608-10TR
Size / count: 20 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: ADP-ribosyltransferase diphtheria toxin-like 1 antibody ADPRT 1 antibody ADPRT antibody ADPRT1 antibody APOPAIN antibody ARTD1 antibody NAD (+) ADP-ribosyltransferase 1 antibody PARP antibody PARP-1 antibody PARP1 antibody PARP1_HUMAN antibody Poly [ADP-ribose] polymerase 1 antibody Poly ADP ribose polymerase 1 antibody Poly[ADP-ribose] synthase 1 antibody PPOL antibody SCA1 antibody
Abbreviation: PARP-1, ARTD1, ADPRT 1, PARP1
Swiss Prot: P09874 Human
Cellular Locus: Nucleus.
Host: Rabbit
Species Reactivity: Human
Immunogen: Synthetic peptide within Human PARP1 aa 200-249 / 1,014.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IF-Cell, IP, FC
Positive Control: Jurkat cell lysate, A549 cell lysate, Hela, Daudi cell lysates.
Concentration: 1 mg/mL
Dilution: WB: 1:500 ;FC: 1:50-1:100 ;IF-Cell: 1:50-1:200 ;IP: Use at an assay dependent concentration.
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 89 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: True

Frequently Asked Questions

What is the catalog number for Anti-Cleaved PARP Antibody [SU0314]?

The catalog number for Anti-Cleaved PARP Antibody [SU0314] is ET1608-10TR.

What sizes are available for Anti-Cleaved PARP Antibody [SU0314]?

Anti-Cleaved PARP Antibody [SU0314] is available in the following size(s): 20 µL.

Is Anti-Cleaved PARP Antibody [SU0314] in stock?

Anti-Cleaved PARP Antibody [SU0314] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Anti-Cleaved PARP Antibody [SU0314] used for?

What buffer is this product supplied in?

The formulation or storage buffer is listed on the product datasheet. If you require a carrier-free or custom formulation, contact us before ordering, as this may involve a made-to-order production timeline.

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.

Can I request a Safety Data Sheet (SDS) for this product?

Yes, safety data sheets are available for hazardous or chemically classified products and can be provided on request or downloaded from the product page.